STRINGSTRING
gpx1b gpx1b hsp70.3 hsp70.3 gpx8 gpx8 gpx1a gpx1a hsp90aa1.1 hsp90aa1.1 mao mao cav3 cav3 cmlc1 cmlc1 ache ache sod2 sod2 pomca pomca gpx3 gpx3 rxraa rxraa esr1 esr1 gpx4a gpx4a nr0b1 nr0b1 hsp70.1 hsp70.1 dgat2 dgat2 gpx7 gpx7 gpx9 gpx9 il6 il6 ENSDARP00000132681 ENSDARP00000132681 pparg pparg gpx4b gpx4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
maoAmine oxidase [flavin-containing]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta- phenylethylamine (PEA); Belongs to the flavin monoamine oxidase family. (522 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
cmlc1Cardiac myosin light chain-1. (196 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
rxraaRetinoic acid receptor RXR-alpha-A; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimer [...] (458 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
dgat2Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity). (366 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
ENSDARP00000132681Amine oxidase. (523 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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