STRINGSTRING
gli2a gli2a fgfr1a fgfr1a fgf8a fgf8a ptch1 ptch1 zic2a zic2a stil stil tdgf1 tdgf1 zic2b zic2b disp1 disp1 six3b six3b ptch2 ptch2 foxh1 foxh1 ndr1 ndr1 six3a six3a tgif1 tgif1 cdon cdon spaw spaw ENSDARP00000125042 ENSDARP00000125042 shha shha sufu sufu
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gli2aGLI family zinc finger 2a. (1439 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
ptch1Protein patched homolog 1. (1475 aa)
zic2aZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa)
stilSCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). (1263 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
zic2bZIC family member 2 (Odd-paired homolog, Drosophila) B. (427 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
six3bSine oculis homeobox homolog 3b. (293 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
ndr1Nodal-related 1. (392 aa)
six3aSine oculis homeobox homolog 3a. (294 aa)
tgif1TGFB-induced factor homeobox 1. (273 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
spawSouthpaw. (411 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
sufuSuppressor of fused homolog. (485 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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