STRINGSTRING
vax2 vax2 ihha ihha ihhb ihhb prkacbb prkacbb mid1 mid1 cdon cdon arl3b arl3b ocrl ocrl kif3a kif3a otx2b otx2b cdk20 cdk20 Q5RHR2_DANRE Q5RHR2_DANRE ENSDARP00000125042 ENSDARP00000125042 E7FC63_DANRE E7FC63_DANRE lrp2a lrp2a sufu sufu prkacaa prkacaa pax6a pax6a dhcr7 dhcr7 gpr161 gpr161 ptch2 ptch2 pax2a pax2a bmp4 bmp4 stra6 stra6 ift172 ift172 dhh dhh casp9 casp9 kif7 kif7 vax1 vax1 vsx2 vsx2 gsk3ba gsk3ba ptch1 ptch1 prkacba prkacba fgfr1a fgfr1a smo smo gli2a gli2a prkacab prkacab
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vax2Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
mid1Midline 1. (667 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
arl3bADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the ciliary membrane by releasing myristoylated protein from unc119 cargo adapters into the cilium (By similarity). (182 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
otx2bHomeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa)
cdk20Cyclin-dependent kinase 20; Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (344 aa)
Q5RHR2_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
ENSDARP00000125042Patched 1. (120 aa)
E7FC63_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
sufuSuppressor of fused homolog. (485 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
dhcr77-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). (478 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
stra6Receptor for retinol uptake stra6; Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol- binding protein rbp1. Required for normal vitamin A homeostasis. (670 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
vax1Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa)
vsx2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
ptch1Protein patched homolog 1. (1475 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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