STRINGSTRING
ccna1 ccna1 dmd dmd casp3a casp3a foxm1 foxm1 myod1 myod1 myog myog tlr3 tlr3 stat1a stat1a bgna bgna tmod2 tmod2 prkcda prkcda myf6 myf6 tnnt2c tnnt2c bgnb bgnb hdac1 hdac1 sirt3 sirt3 cxcl12a cxcl12a egr1 egr1 gapdhs gapdhs ccl38a.5 ccl38a.5 gapdh gapdh cdc45 cdc45 pcna pcna casp3b casp3b ikbke ikbke fstb fstb pleca pleca cdk4 cdk4 ppargc1a ppargc1a mef2ca mef2ca myh7 myh7 tnnc2 tnnc2 edn1 edn1 myot myot hdac5 hdac5 vclb vclb tmod1 tmod1 vcla vcla pparaa pparaa myh6 myh6 cdk1 cdk1 myf5 myf5 cebpd cebpd tmod4 tmod4 mef2d mef2d tp53 tp53 mef2aa mef2aa neb neb bcl2a bcl2a fsta fsta sgca sgca egfra egfra pparab pparab ehmt2 ehmt2 pxdn pxdn tln1 tln1 fgf2 fgf2 tln2a tln2a e2f1 e2f1 hdac4 hdac4 smyhc1 smyhc1 tnnt1 tnnt1 eef1a1l1 eef1a1l1 tln2b tln2b Itga7 Itga7 plecb plecb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
dmdDystrophin. (594 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
foxm1Forkhead box M1. (623 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
bgnaBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (369 aa)
tmod2Tropomodulin 2. (344 aa)
prkcdaProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
bgnbBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (374 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
sirt3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (357 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
egr1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
ccl38a.5C-C motif chemokine. (103 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
fstbFollistatin 2. (344 aa)
plecaPlectin a. (4577 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (297 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
myh7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
edn1Endothelin 1. (188 aa)
myotMyotilin. (561 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
vclbVinculin b. (987 aa)
tmod1Tropomodulin 1. (356 aa)
vclaVinculin a. (1131 aa)
pparaaPeroxisome proliferator-activated receptor alpha a. (470 aa)
myh6Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
cdk1Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa)
myf5Myogenic factor. (237 aa)
cebpdCCAAT/enhancer-binding protein. (280 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
mef2aaMyocyte enhancer factor 2aa. (458 aa)
nebNebulin. (6177 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
sgcaSarcoglycan, alpha. (377 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
ehmt2Euchromatic histone-lysine N-methyltransferase 2. (1167 aa)
pxdnPeroxidasin. (1460 aa)
tln1Talin 1. (2544 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
tln2aTalin 2a. (2543 aa)
e2f1E2F transcription factor 1. (429 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
tln2bTalin 2b. (1537 aa)
Itga7Uncharacterized protein. (156 aa)
plecbPlectin b. (4535 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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