STRINGSTRING
rad51c rad51c cdk12 cdk12 ptenb ptenb cdkn1bb cdkn1bb fancd2 fancd2 hoxa2b hoxa2b braf braf brd2a brd2a idh2 idh2 foxl1 foxl1 mycn mycn idh1 idh1 ezh2 ezh2 cul3a cul3a aurka aurka etv4 etv4 atm atm dlx1a dlx1a TCERG1L TCERG1L kras kras hrasa hrasa ctnnb1 ctnnb1 gstp1 gstp1 foxa1 foxa1 rest rest tmprss2 tmprss2 cul3b cul3b msh6 msh6 chd1 chd1 ncam1a ncam1a med12 med12 spop spop pik3r2 pik3r2 etv1 etv1 actl6b actl6b plat plat rassf1 rassf1 brd3a brd3a tp53 tp53 fbxw7 fbxw7 nrcama nrcama hoxc6a hoxc6a mtor mtor slc45a3 slc45a3 chgb chgb brd4 brd4 myca myca brca2 brca2 ttn.2 ttn.2 sox2 sox2 pik3c3 pik3c3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad51cRAD51 paralog C. (362 aa)
cdk12Cyclin-dependent kinase 12. (1293 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
fancd2FA complementation group D2. (1445 aa)
hoxa2bHomeobox protein Hox-A2b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (363 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (817 aa)
brd2aBromodomain-containing protein 2a. (836 aa)
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)
foxl1Forkhead transcription factor. (360 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (429 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
cul3aCullin 3a; Belongs to the cullin family. (774 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
etv4ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
dlx1aHomeobox protein Dlx1a. (252 aa)
TCERG1LTranscription elongation regulator 1 like. (589 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
hrasaHRas proto-oncogene, GTPase a. (189 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
gstp1Pi-class glutathione S-transferase; Belongs to the GST superfamily. (208 aa)
foxa1Forkhead box A1. (427 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
tmprss2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (487 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1369 aa)
chd1Chromodomain helicase DNA-binding protein 1. (1777 aa)
ncam1aNeural cell adhesion molecule 1a. (898 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
spopSpeckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Belongs to the Tdpoz family. (374 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
etv1ETS variant transcription factor 1. (476 aa)
actl6bActin-like 6B; Belongs to the actin family. (426 aa)
platPlasminogen activator; Belongs to the peptidase S1 family. (578 aa)
rassf1Ras association domain family member 1. (321 aa)
brd3aBromodomain-containing 3a. (683 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
fbxw7F-box and WD repeat domain-containing 7. (544 aa)
nrcamaNeuronal cell adhesion molecule a. (1285 aa)
hoxc6aHomeobox protein Hox-C6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (208 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
slc45a3Solute carrier family 45 member 3. (537 aa)
chgbChromogranin B. (676 aa)
brd4Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] (1444 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
brca2BRCA2 DNA repair-associated. (2874 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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