STRINGSTRING
nphp4 nphp4 angpt1 angpt1 kdr kdr acta1b acta1b ift172 ift172 nphp1 nphp1 angpt2b angpt2b rpgra rpgra mak mak toporsa toporsa rhol rhol ocrl ocrl cyp1b1 cyp1b1 rpgrip1l rpgrip1l rpgrip1 rpgrip1 rp2 rp2 prpf31 prpf31 trpv4 trpv4 ahi1 ahi1 cep290 cep290 opn6b opn6b iqcb1 iqcb1 kdrl kdrl Exorh Exorh tub tub opn1mw4 opn1mw4 opn1mw1 opn1mw1 opn1mw3 opn1mw3 flt1 flt1 rho rho opn1mw2 opn1mw2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nphp4Si:dkey-202c5.1 protein. (189 aa)
angpt1Angiopoietin 1. (513 aa)
kdrVascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
nphp1Nephronophthisis 1. (667 aa)
angpt2bAngiopoietin 2b. (489 aa)
rpgraRetinitis pigmentosa GTPase regulator a. (1698 aa)
makMale germ cell-associated kinase. (633 aa)
toporsaTopoisomerase I-binding, arginine/serine-rich a. (999 aa)
rholRhodopsin. (355 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
cyp1b1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
rpgrip1lRPGRIP1-like. (1256 aa)
rpgrip1RPGR-interacting protein 1. (1342 aa)
rp2Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa)
prpf31U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. (508 aa)
trpv4Transient receptor potential cation channel, subfamily V, member 4. (856 aa)
ahi1Abelson helper integration site 1. (1193 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
opn6bOpsin 6, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (391 aa)
iqcb1IQ motif-containing B1. (595 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
ExorhRhodopsin. (168 aa)
tubTUB bipartite transcription factor; Belongs to the TUB family. (509 aa)
opn1mw4Green-sensitive opsin-4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (349 aa)
opn1mw1Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (349 aa)
opn1mw3Green-sensitive opsin-3; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (349 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
opn1mw2Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (349 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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