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| | gli3 | GLI family zinc finger 3. (1553 aa) |
| | snai2 | Snail homolog 2 (Drosophila). (257 aa) |
| | shhb | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa) |
| | aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (320 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | nr3c1 | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa) |
| | zic2b | ZIC family member 2 (Odd-paired homolog, Drosophila) B. (427 aa) |
| | npc2 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] (149 aa) |
| | hmgb2a | High mobility group box 2a. (213 aa) |
| | hif1aa | Hypoxia-inducible factor 1 subunit alpha a. (717 aa) |
| | twist1a | Twist family bHLH transcription factor 1a. (171 aa) |
| | pax3a | Transcription factor PAX3. (509 aa) |
| | fzd5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | ets1 | V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa) |
| | smad1 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | rhogb | Ras homolog gene family, member Gb. (191 aa) |
| | mycn | N-myc protein; May function as a transcription factor. (503 aa) |
| | zic2a | ZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa) |
| | tbx3a | T-box transcription factor 3a. (689 aa) |
| | dlx3b | Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa) |
| | aurka | Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa) |
| | fabp7a | Fatty acid-binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | mafba | Transcription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | isl1 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | fezf1 | Fez family zinc finger protein 1; Transcription repressor. Involved in the development of the forebrain region (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (429 aa) |
| | dlx2b | Homeobox protein Dlx2b. (276 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | hif1ab | Hypoxia-inducible factor 1 subunit alpha b. (777 aa) |
| | sox4a | Transcription factor SOX. (363 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | tfap2a | Transcription factor AP-2 alpha. (450 aa) |
| | tjp1a | Tight junction protein 1a; Belongs to the MAGUK family. (1689 aa) |
| | hmgb2b | High mobility group box 2b. (214 aa) |
| | tbxtb | T-box transcription factor Tb. (427 aa) |
| | msx1a | Muscle segment homeobox 1a. (233 aa) |
| | lpar4 | Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | ift20 | Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. (132 aa) |
| | npc1 | Niemann-Pick disease, type C1. (1277 aa) |
| | ebf1b | EBF transcription factor 1b. (603 aa) |
| | arid3a | AT-rich interactive domain-containing protein 3A. (524 aa) |
| | zeb2a | Zinc finger E-box-binding homeobox 2a. (1242 aa) |
| | anln | Anillin, actin-binding protein. (1171 aa) |
| | tfap2b | Transcription factor AP-2 beta. (439 aa) |
| | pparg | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | irf1b | Interferon regulatory factor. (287 aa) |
| | irx3a | Iroquois 3 homeobox protein. (454 aa) |
| | irf6 | Interferon regulatory factor 6. (492 aa) |
| | LIN28A | Si:ch1073-284b18.2. (193 aa) |
| | pax7a | Transcription factor PAX7C. (507 aa) |
| | wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | cdh1 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa) |
| | sox13 | SRY-box transcription factor 13. (597 aa) |
| | pax6a | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa) |
| | prom1a | Prominin-1-A; May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. Involved in regulation of MAPK and Akt signaling pathways (By similarity); Belongs to the prominin family. (849 aa) |
| | foxo1a | Forkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa) |
| | cntn4 | Contactin 4. (1028 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | rela | V-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa) |
| | etv1 | ETS variant transcription factor 1. (476 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | grhl2b | Grainyhead-like transcription factor 2b. (601 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | tfap2c | Transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma). (445 aa) |
| | klf5b | Kruppel-like factor 5b. (344 aa) |
| | nr2f1a | Nuclear receptor subfamily 2 group F member 1-A; Putative transcription factor that is required in photoreceptor cells precursors during eye development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (411 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | ephb6 | Receptor protein-tyrosine kinase. (1009 aa) |
| | runx1 | Runt-related transcription factor. (451 aa) |
| | ednrba | Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa) |
| | otx2b | Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa) |
| | prdm14 | PR domain-containing 14. (568 aa) |
| | junba | JunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa) |
| | foxd3 | Forkhead box D3. (371 aa) |
| | bmi1a | Polycomb complex protein BMI-1-A; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2. (322 aa) |
| | zic1 | ZIC family member 1 (Odd-paired homolog, Drosophila). (442 aa) |
| | zic4 | Zinc finger of the cerebellum 4. (530 aa) |
| | mafb | Transcription factor Maf; Acts as a transcriptional activator or repressor. Belongs to the bZIP family. Maf subfamily. (327 aa) |
| | dlx5a | Homeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa) |
| | f11r.1 | F11 receptor, tandem duplicate 1. (292 aa) |
| | itga6a | Integrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa) |
| | grhl3 | Grainyhead-like transcription factor 3. (557 aa) |
| | zic3 | ZIC family member 3 heterotaxy 1 (Odd-paired homolog, Drosophila). (448 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | sox2 | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa) |
| | foxg1a | Forkhead box G1a. (420 aa) |
| | dlx6a | Homeobox protein Dlx6a. (247 aa) |
| | lin28a | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (202 aa) |
| | arid3c | AT-rich interactive domain-containing protein 3A; Transcription factor. (570 aa) |
| | six3a | Sine oculis homeobox homolog 3a. (294 aa) |
| | lhx5 | LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon. (399 aa) |
| | raraa | Retinoic acid receptor alpha-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning; Belongs to the nuclear hormone receptor family. NR1 subfamily. (444 aa) |
| | six3b | Sine oculis homeobox homolog 3b. (293 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | angpt2b | Angiopoietin 2b. (489 aa) |
| | irf1a | Interferon regulatory factor. (251 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | egf | Epidermal growth factor. (1114 aa) |
| | wnt7aa | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | sall4 | Spalt-like transcription factor 4. (1091 aa) |
| | otx1 | Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa) |
| | yy1a | YY1 transcription factor a. (357 aa) |
