STRINGSTRING
tgfb1b tgfb1b sox4a sox4a pou4f1 pou4f1 mycb mycb bdnf bdnf ptf1a ptf1a isl1 isl1 foxn4 foxn4 tgfb3 tgfb3 isl1l isl1l neurod1 neurod1 onecut1 onecut1 elavl3 elavl3 vsx2 vsx2 socs3a socs3a fosab fosab slit1b slit1b sncgb sncgb shha shha pou4f3 pou4f3 gdnfa gdnfa onecutl onecutl fsta fsta sncga sncga m17 m17 casz1 casz1 map2 map2 pou4f2 pou4f2 slit1a slit1a myca myca klf4 klf4 tgfb5 tgfb5 atoh7 atoh7 ntf3 ntf3 six3a six3a fstb fstb ikzf1 ikzf1 ptenb ptenb six3b six3b pou5f3 pou5f3 tgfb1a tgfb1a calb2a calb2a shhb shhb klf17 klf17 calb2b calb2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
sox4aTranscription factor SOX. (363 aa)
pou4f1POU domain protein. (368 aa)
mycbTranscriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
ptf1aPancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
foxn4Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] (550 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
isl1lIslet1,-like. (323 aa)
neurod1Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (350 aa)
onecut1One cut domain family member. (461 aa)
elavl3ELAV-like protein; Belongs to the RRM elav family. (359 aa)
vsx2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
slit1bSlit homolog 1b (Drosophila). (1532 aa)
sncgbSynuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family. (114 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
gdnfaGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa)
onecutlOne cut domain family member. (450 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
sncgaSynuclein, gamma a; Belongs to the synuclein family. (111 aa)
m17IL-6 subfamily cytokine M17. (219 aa)
casz1Castor zinc finger 1. (1644 aa)
map2Microtubule-associated protein 2. (248 aa)
pou4f2POU domain protein. (384 aa)
slit1aSlit homolog 1a (Drosophila). (1524 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
klf4Kruppel-like factor 4. (340 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
atoh7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (243 aa)
six3aSine oculis homeobox homolog 3a. (294 aa)
fstbFollistatin 2. (344 aa)
ikzf1IKAROS family zinc finger 1 (Ikaros). (526 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
six3bSine oculis homeobox homolog 3b. (293 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
calb2aCalbindin 2, like. (271 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
klf17Kruppel-like factor 17. (409 aa)
calb2bCalbindin 2b. (269 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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