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actn3b actn3b myod1 myod1 cdkn1ca cdkn1ca tcf3a tcf3a myog myog hsp70l hsp70l pax3a pax3a myf6 myf6 hist2h2l hist2h2l gapdhs gapdhs gapdh gapdh acta1b acta1b mylpfa mylpfa jam3b jam3b myhz1.1 myhz1.1 ttn.1 ttn.1 hsp70.1 hsp70.1 myf5 myf5 actb2 actb2 X1WHF1_DANRE X1WHF1_DANRE mymk mymk jam2a jam2a pax7a pax7a smyhc1 smyhc1 kirrel3l kirrel3l hrasa hrasa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
cdkn1caCyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa)
tcf3aTranscription factor 3a. (570 aa)
myogMyogenin. (256 aa)
hsp70lNovel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa)
pax3aTranscription factor PAX3. (509 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
jam3bJunctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
myf5Myogenic factor. (237 aa)
actb2Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
mymkProtein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. (220 aa)
jam2aJunctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. (307 aa)
pax7aTranscription factor PAX7C. (507 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
kirrel3lKirre-like nephrin family adhesion molecule 3, like. (755 aa)
hrasaHRas proto-oncogene, GTPase a. (189 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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