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c1qb c1qb ddx3xa ddx3xa dmrt2a dmrt2a chchd10 chchd10 smcr8b smcr8b C13H9orf72 C13H9orf72 chmp2bb chmp2bb vcp vcp lsm4 lsm4 c1qa c1qa keap1a keap1a hnrnpa1b hnrnpa1b fus fus chmp2ba chmp2ba psap psap atg101 atg101 tia1 tia1 F1QQY3_DANRE F1QQY3_DANRE ctsd ctsd atxn2 atxn2 atp13a2 atp13a2 src src gba gba rabif rabif c1qc c1qc mtor mtor wdr41 wdr41 tmem106bb tmem106bb sqstm1 sqstm1 sort1b sort1b rab8a rab8a sort1a sort1a tbk1 tbk1 itgam itgam slc1a2b slc1a2b ctsc ctsc prkar1b prkar1b csf1ra csf1ra nphs1 nphs1 tfeb tfeb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
c1qbComplement component 1, q subcomponent, B chain. (242 aa)
ddx3xaDEAD-box helicase 3 X-linked a; Belongs to the DEAD box helicase family. (709 aa)
dmrt2aDoublesex and mab-3-related transcription factor 2a. (507 aa)
chchd10Coiled-coil-helix-coiled-coil-helix domain-containing 10. (143 aa)
smcr8bGuanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa)
C13H9orf72Zgc:100846. (462 aa)
chmp2bbCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
lsm4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (143 aa)
c1qaComplement component 1, q subcomponent, A chain. (247 aa)
keap1aKelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (601 aa)
hnrnpa1bHeterogeneous nuclear ribonucleoprotein A1b. (403 aa)
fusFUS RNA-binding protein. (541 aa)
chmp2baCharged multivesicular body protein 2Ba. (216 aa)
psapProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (520 aa)
atg101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa)
tia1TIA1 cytotoxic granule-associated RNA-binding protein. (386 aa)
F1QQY3_DANRESortilin. (423 aa)
ctsdCtsd protein; Belongs to the peptidase A1 family. (398 aa)
atxn2Ataxin 2. (1112 aa)
atp13a2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1170 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
gbaGlucosylceramidase. (518 aa)
rabifRAB-interacting factor. (132 aa)
c1qcComplement component 1, q subcomponent, C chain. (244 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
wdr41WD repeat domain 41. (449 aa)
tmem106bbTransmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking; Belongs to the TMEM106 family. (267 aa)
sqstm1Sequestosome 1. (452 aa)
sort1bSortilin. (828 aa)
rab8aRAB8A, member RAS oncogene family. (207 aa)
sort1aSortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Belongs to the VPS10-related sortilin family. SORT1 subfamily. (815 aa)
tbk1TANK-binding kinase 1. (727 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
slc1a2bAmino acid transporter. (564 aa)
ctscCathepsin C; Belongs to the peptidase C1 family. (455 aa)
prkar1bProtein kinase, cAMP-dependent, regulatory, type I, beta. (380 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
nphs1NPHS1 adhesion molecule, nephrin. (1287 aa)
tfebTranscription factor EB. (493 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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