STRINGSTRING
fbl fbl emg1 emg1 tent4b tent4b dis3 dis3 nhp2 nhp2 myca myca rps26 rps26 rrs1 rrs1 dis3l2 dis3l2 rps28 rps28 tp53 tp53 sbds sbds nop10 nop10 isg20l2 isg20l2 xrn2 xrn2 parn parn dnajc21 dnajc21 gata1a gata1a utp4 utp4 ada ada rpl27 rpl27 tsr2 tsr2 rps19 rps19 bms1 bms1 rpl11 rpl11 rpf2 rpf2 eri1 eri1 ada2a ada2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fblFibrillarin. (317 aa)
emg1EMG1 N1-specific pseudouridine methyltransferase. (238 aa)
tent4bTerminal nucleotidyltransferase 4B. (653 aa)
dis3DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (950 aa)
nhp2H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (150 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
rrs1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (346 aa)
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (995 aa)
rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
sbdsSBDS ribosome maturation factor. (250 aa)
nop10H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (64 aa)
isg20l2Interferon-stimulated exonuclease gene 20-like 2. (321 aa)
xrn25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (952 aa)
parnPoly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (By similarity). (660 aa)
dnajc21DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. (545 aa)
gata1aGATA-binding protein 1a. (418 aa)
utp4Cirrhosis, autosomal recessive 1A (Cirhin). (685 aa)
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (362 aa)
rpl2760S ribosomal protein L27; Component of the large ribosomal subunit. (136 aa)
tsr2Pre-rRNA-processing protein TSR2 homolog; May be involved in 20S pre-rRNA processing. (182 aa)
rps19Ribosomal protein S19. (146 aa)
bms1BMS1 ribosome biogenesis factor. (1221 aa)
rpl1160S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
rpf2Ribosome production factor 2 homolog. (308 aa)
eri1Exoribonuclease 1. (337 aa)
ada2aAdenosine deaminase 2-A; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. May play a role in the regulation of cell proliferation (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily. (503 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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