node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aspm | fign | ENSDARP00000135909 | ENSDARP00000152560 | Abnormal spindle microtubule assembly. | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | 0.406 |
aspm | katnal1 | ENSDARP00000135909 | ENSDARP00000131532 | Abnormal spindle microtubule assembly. | Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). | 0.548 |
aspm | katnb1 | ENSDARP00000135909 | ENSDARP00000024623 | Abnormal spindle microtubule assembly. | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | 0.762 |
cfl1 | cfl1l | ENSDARP00000023177 | ENSDARP00000006420 | Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. | Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. | 0.905 |
cfl1 | cfl2 | ENSDARP00000023177 | ENSDARP00000006783 | Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | 0.901 |
cfl1l | cfl1 | ENSDARP00000006420 | ENSDARP00000023177 | Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. | Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. | 0.905 |
cfl1l | cfl2 | ENSDARP00000006420 | ENSDARP00000006783 | Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | 0.904 |
cfl2 | cfl1 | ENSDARP00000006783 | ENSDARP00000023177 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. | 0.901 |
cfl2 | cfl1l | ENSDARP00000006783 | ENSDARP00000006420 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. | 0.904 |
chmp1b | fign | ENSDARP00000134015 | ENSDARP00000152560 | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | 0.595 |
chmp1b | katnb1 | ENSDARP00000134015 | ENSDARP00000024623 | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | 0.528 |
fign | aspm | ENSDARP00000152560 | ENSDARP00000135909 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | Abnormal spindle microtubule assembly. | 0.406 |
fign | chmp1b | ENSDARP00000152560 | ENSDARP00000134015 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. | 0.595 |
fign | katnb1 | ENSDARP00000152560 | ENSDARP00000024623 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | 0.731 |
katnal1 | aspm | ENSDARP00000131532 | ENSDARP00000135909 | Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). | Abnormal spindle microtubule assembly. | 0.548 |
katnal1 | katnb1 | ENSDARP00000131532 | ENSDARP00000024623 | Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | 0.986 |
katnb1 | aspm | ENSDARP00000024623 | ENSDARP00000135909 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | Abnormal spindle microtubule assembly. | 0.762 |
katnb1 | chmp1b | ENSDARP00000024623 | ENSDARP00000134015 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. | 0.528 |
katnb1 | fign | ENSDARP00000024623 | ENSDARP00000152560 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] | 0.731 |
katnb1 | katnal1 | ENSDARP00000024623 | ENSDARP00000131532 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. | Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). | 0.986 |