STRINGSTRING
clrn1 clrn1 ubr3 ubr3 ush1ga ush1ga magi2a magi2a cdh23 cdh23 acta1b acta1b myo6b myo6b trappc3 trappc3 ush1c ush1c grxcr1b grxcr1b myo7aa myo7aa pcdh15a pcdh15a ush1gb ush1gb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
clrn1Clrn1 protein. (232 aa)
ubr3E3 ubiquitin-protein ligase ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7. (1863 aa)
ush1gaUsher syndrome 1Ga (autosomal recessive). (472 aa)
magi2aMembrane-associated guanylate kinase, WW and PDZ domain-containing 2a. (1503 aa)
cdh23Cadherin-related 23. (2883 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
myo6bMyosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa)
trappc3Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
grxcr1bGlutaredoxin and cysteine-rich domain-containing 1 b. (148 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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