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actn3b actn3b RYR2 RYR2 megf10 megf10 pparg pparg kbtbd13 kbtbd13 Trdn Trdn smyhc2-2 smyhc2-2 dnm2a dnm2a ryr2b ryr2b casq1a casq1a tpm2 tpm2 ryr3 ryr3 tpm3 tpm3 mtm1 mtm1 ryr1a ryr1a selenon selenon ttn.2 ttn.2 trdn trdn mstnb mstnb myh7 myh7 asph asph mtmr14 mtmr14 bin1b bin1b acta1b acta1b ache ache atp2a1 atp2a1 ccdc78 ccdc78 ryr1b ryr1b cfl1 cfl1 casq2 casq2 vim vim casq1b casq1b myod1 myod1 cfl2 cfl2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
RYR2Uncharacterized protein. (4478 aa)
megf10Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
kbtbd13Kelch repeat and BTB (POZ) domain-containing 13. (473 aa)
TrdnSi:ch211-199i15.5. (118 aa)
smyhc2-2Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
dnm2aDynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa)
ryr2bRyanodine receptor 2b (cardiac). (4878 aa)
casq1aCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (553 aa)
tpm2Tropomyosin 2 (beta); Belongs to the tropomyosin family. (284 aa)
ryr3Ryanodine receptor 3. (4987 aa)
tpm3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
mtm1Myotubularin 1. (639 aa)
ryr1aRyanodine receptor 1a (skeletal). (5062 aa)
selenonSelenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
trdnTriadin. (785 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
myh7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
asphAspartate beta-hydroxylase. (472 aa)
mtmr14Myotubularin-related protein 14. (630 aa)
bin1bBridging integrator 1b. (364 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
ccdc78Coiled-coil domain-containing 78. (547 aa)
ryr1bRyanodine receptor 1b (skeletal). (5078 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
casq2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
casq1bCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (454 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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