STRINGSTRING
rad21a rad21a ubc ubc cdkn2c cdkn2c ccnb3 ccnb3 skp2 skp2 cdc7 cdc7 ar ar esr1 esr1 gnrh3 gnrh3 pcna pcna rbl2 rbl2 dbf4 dbf4 ccnb1 ccnb1 ccnb2 ccnb2 orc3 orc3 UBB UBB elavl3 elavl3 ccna1 ccna1 fabp7a fabp7a cdc6 cdc6 cks1b cks1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
ubcUbiquitin C. (533 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (170 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (398 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (459 aa)
arAndrogen receptor. (868 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
gnrh3Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (94 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rbl2Retinoblastoma-like 2 (p130). (1079 aa)
dbf4DBF4 zinc finger. (612 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (397 aa)
ccnb2Cyclin B2; Belongs to the cyclin family. (386 aa)
orc3Origin recognition complex, subunit 3. (706 aa)
UBBSi:ch211-202a12.4. (459 aa)
elavl3ELAV-like protein; Belongs to the RRM elav family. (359 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
fabp7aFatty acid-binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
cks1bCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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