STRINGSTRING
rnf4 rnf4 tbk1 tbk1 sumo2a sumo2a X1WHF1_DANRE X1WHF1_DANRE faap100 faap100 tp53 tp53 usp46 usp46 fanci fanci fancf fancf fancl fancl usp48 usp48 sumo3b sumo3b isg15 isg15 rad18 rad18 ube2t ube2t usp18 usp18 usp12a usp12a hist1h2a3 hist1h2a3 fance fance fancc fancc fancb fancb usp30 usp30 usp1 usp1 pcna pcna usp11 usp11 fancd2 fancd2 wdr48b wdr48b hist2h2l hist2h2l usp7 usp7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf4Ring finger protein 4. (184 aa)
tbk1TANK-binding kinase 1. (727 aa)
sumo2aSmall ubiquitin-related modifier. (94 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
faap100Si:dkey-57h18.1. (830 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
usp46Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity). (370 aa)
fanciFA complementation group I. (1327 aa)
fancfFA complementation group F. (333 aa)
fanclFA complementation group L. (371 aa)
usp48Ubiquitin-specific peptidase 48; Belongs to the peptidase C19 family. (1092 aa)
sumo3bSmall ubiquitin-related modifier. (94 aa)
isg15ISG15 ubiquitin-like modifier. (157 aa)
rad18RAD18 E3 ubiquitin protein ligase. (426 aa)
ube2tUbiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
usp18Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. (337 aa)
usp12aUbiquitin carboxyl-terminal hydrolase 12A; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity. (371 aa)
hist1h2a3Histone H2A; Belongs to the histone H2A family. (128 aa)
fanceFanconi anemia, complementation group E. (502 aa)
fanccFA complementation group C. (554 aa)
fancbFA complementation group B. (796 aa)
usp30Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (491 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (772 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
usp11Ubiquitin carboxyl-terminal hydrolase. (990 aa)
fancd2FA complementation group D2. (1445 aa)
wdr48bWD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
usp7Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1110 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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