STRINGSTRING
tm4sf4 tm4sf4 f11r.1 f11r.1 myca myca g0s2 g0s2 abcg8 abcg8 serpina1 serpina1 nr0b1 nr0b1 nr1i2 nr1i2 f10 f10 pparaa pparaa lrp5 lrp5 plin2 plin2 esr2a esr2a cyp19a1a cyp19a1a gcgb gcgb cyp7a1 cyp7a1 dgat2 dgat2 esr2b esr2b fpgs fpgs ghrl ghrl soat1 soat1 uox uox tac1 tac1 serpinf2a serpinf2a abcb4 abcb4 hdc hdc pparab pparab abca1a abca1a mst1 mst1 esm1 esm1 snx7 snx7 hpdl hpdl gata4 gata4 igfbp1a igfbp1a fgf19 fgf19 irs2b irs2b HPDL HPDL gata6 gata6 foxa1 foxa1 dgat1a dgat1a il6r il6r ednraa ednraa pck2 pck2 gnmt gnmt mogat2 mogat2 oclna oclna tnfrsf1a tnfrsf1a ambp ambp ghra ghra hpda hpda fgb fgb krt4 krt4 ttc36 ttc36 mcamb mcamb mogat3b mogat3b slc18a2 slc18a2 cpa1 cpa1 abcc2 abcc2 hsd3b2 hsd3b2 gata5 gata5 dab2 dab2 fga fga cpa5 cpa5 galk1 galk1 th th prrx1a prrx1a twist1a twist1a ldlra ldlra enpp2 enpp2 htra1a htra1a cd36 cd36 f2 f2 txnipa txnipa calb2b calb2b fgg fgg cfd cfd gapdhs gapdhs apoeb apoeb adra2a adra2a lgi3 lgi3 hsd3b1 hsd3b1 nr1h4 nr1h4 nfe2l2a nfe2l2a pomca pomca pcyt2 pcyt2 gapdh gapdh sod1 sod1 hpdb hpdb arl4d arl4d vtnb vtnb tgfa tgfa krt8 krt8 gata2a gata2a gck gck lss lss aoc1 aoc1 esr1 esr1 satb2 satb2 abcg5 abcg5 dpep1 dpep1 bsx bsx tat tat
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tm4sf4Transmembrane 4 L six family member 4. (198 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
g0s2Hypothetical LOC568476. (162 aa)
abcg8ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
serpina1Serine (Or cysteine) proteinase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 1; Belongs to the serpin family. (429 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
nr1i2Nuclear receptor subfamily 1, group I, member 2. (430 aa)
f10Coagulation factor X. (504 aa)
pparaaPeroxisome proliferator-activated receptor alpha a. (470 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
plin2Perilipin; Belongs to the perilipin family. (444 aa)
esr2aEstrogen receptor beta2. (553 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
gcgbGlucagon b. (124 aa)
cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
dgat2Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity). (366 aa)
esr2bEstrogen receptor 2b. (592 aa)
fpgsFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (572 aa)
ghrlGhrelin/obestatin prepropeptide. (104 aa)
soat1O-acyltransferase. (554 aa)
uoxUricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (298 aa)
tac1Tachykinin precursor 1. (114 aa)
serpinf2aAlpha-2-antiplasmin; Belongs to the serpin family. (457 aa)
abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 4. (1275 aa)
hdcHistidine decarboxylase. (484 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
abca1aATP-binding cassette, sub-family A (ABC1), member 1A. (2268 aa)
mst1Macrophage stimulating 1 (Hepatocyte growth factor-like); Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa)
esm1Endothelial cell-specific molecule 1. (179 aa)
snx7Sorting nexin 7. (435 aa)
hpdl4-hydroxyphenylpyruvate dioxygenase. (420 aa)
gata4GATA-binding protein 4. (352 aa)
igfbp1aInsulin-like growth factor-binding protein 1a. (262 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
irs2bInsulin receptor substrate 2b. (1062 aa)
HPDL4-hydroxyphenylpyruvate dioxygenase. (420 aa)
gata6GATA-binding protein 6. (501 aa)
foxa1Forkhead box A1. (427 aa)
dgat1aO-acyltransferase. (499 aa)
il6rInterleukin 6 receptor. (604 aa)
ednraaEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa)
pck2Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (636 aa)
gnmtGlycine N-methyltransferase. (294 aa)
mogat2Monoacylglycerol O-acyltransferase 2. (252 aa)
oclnaOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (491 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
ambpAlpha-1-microglobulin/bikunin precursor. (346 aa)
ghraGrowth hormone receptor a. (570 aa)
hpda4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (397 aa)
fgbFibrinogen, B beta polypeptide. (485 aa)
krt4Keratin 4; Belongs to the intermediate filament family. (497 aa)
ttc36Tetratricopeptide repeat protein 36; Belongs to the TTC36 family. (187 aa)
mcambMelanoma cell adhesion molecule b. (617 aa)
mogat3bMonoacylglycerol O-acyltransferase 3b. (336 aa)
slc18a2Solute carrier family 18 member 2. (562 aa)
cpa1Carboxypeptidase A1 (pancreatic). (418 aa)
abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 2. (1553 aa)
hsd3b2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (374 aa)
gata5Transcription factor gata5. (383 aa)
dab2DAB adaptor protein 2. (589 aa)
fgaFibrinogen alpha chain. (684 aa)
cpa5Carboxypeptidase A5. (419 aa)
galk1Galactokinase 1. (393 aa)
thTyrosine hydroxylase. (489 aa)
prrx1aPaired-related homeobox 1a. (245 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
ldlraLow density lipoprotein receptor a. (911 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa)
htra1aSerine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] (479 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
f2Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (635 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
calb2bCalbindin 2b. (269 aa)
fggFibrinogen, gamma polypeptide. (431 aa)
cfdComplement factor D (adipsin); Belongs to the peptidase S1 family. (249 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
adra2aAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily. (388 aa)
lgi3Leucine-rich repeat LGI family, member 3. (551 aa)
hsd3b1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
nr1h4Nuclear receptor subfamily 1, group H, member 4. (483 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
pcyt2Phosphate cytidylyltransferase 2, ethanolamine. (397 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
hpdb4-hydroxyphenylpyruvate dioxygenase. (393 aa)
arl4dADP-ribosylation factor-like 4D. (200 aa)
vtnbVitronectin b. (449 aa)
tgfaTransforming growth factor, alpha. (191 aa)
krt8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. (520 aa)
gata2aGATA-binding protein 2a. (456 aa)
gckPhosphotransferase. (298 aa)
lssTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (735 aa)
aoc1Amine oxidase. (742 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
satb2DNA-binding protein SATB. (834 aa)
abcg5ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
dpep1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (414 aa)
bsxBrain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (227 aa)
tatTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (444 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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