STRINGSTRING
gata3 gata3 Dlk1 Dlk1 rarres3 rarres3 notch1a notch1a gata6 gata6 gata4 gata4 bmper bmper phox2bb phox2bb ifng1 ifng1 lmo2 lmo2 mybl2a mybl2a il4 il4 tal1 tal1 gata2a gata2a hoxb7a hoxb7a gata1a gata1a id3 id3 myb myb bmp4 bmp4 notch1b notch1b th th runx1 runx1 pax5 pax5 il13 il13 thpo thpo ptprc ptprc agpat5 agpat5 spi1b spi1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gata3Transcription factor GATA-3. (438 aa)
Dlk1Uncharacterized protein. (286 aa)
rarres3Retinoic acid receptor responder 3. (165 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
gata6GATA-binding protein 6. (501 aa)
gata4GATA-binding protein 4. (352 aa)
bmperBMP-binding endothelial regulator. (667 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
ifng1Interferon gamma 1. (179 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
mybl2aV-myb avian myeloblastosis viral oncogene homolog-like 2a. (802 aa)
il4Interleukin-4. (127 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
gata2aGATA-binding protein 2a. (456 aa)
hoxb7aHomeobox protein Hox-B7a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (227 aa)
gata1aGATA-binding protein 1a. (418 aa)
id3Inhibitor of DNA binding 3. (116 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
notch1bNotch receptor 1b. (2465 aa)
thTyrosine hydroxylase. (489 aa)
runx1Runt-related transcription factor. (451 aa)
pax5Paired box 5. (396 aa)
il13Interleukin 4/13A. (157 aa)
thpoThrombopoietin. (191 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
agpat51-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon). (365 aa)
spi1bSI:bY184L24.2.1 (Transcription factor spi1). (296 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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