STRINGSTRING
ntn2 ntn2 flt1 flt1 cdh2 cdh2 hif1ab hif1ab cfl1l cfl1l cfl2 cfl2 A3KQ53_DANRE A3KQ53_DANRE sema3b sema3b rhoab rhoab plxna4 plxna4 sgk2b sgk2b cfl1 cfl1 sgk1 sgk1 ntn1b ntn1b abl2 abl2 hif1aa hif1aa zeb1b zeb1b sema3e sema3e acta1b acta1b snai1b snai1b ctsba ctsba foxp3a foxp3a E7EXX6_DANRE E7EXX6_DANRE furina furina dscamb dscamb furinb furinb LOC100332721 LOC100332721 mtor mtor ciita ciita sema7a sema7a snai1a snai1a plxnd1 plxnd1 plxnc1 plxnc1 tp53 tp53 mlst8 mlst8 rictorb rictorb plxnb1b plxnb1b ntn4 ntn4 hif1al hif1al unc5b unc5b vegfaa vegfaa ntn1a ntn1a cdh1 cdh1 neo1a neo1a notch1a notch1a unc5a unc5a ctsbb ctsbb LOC559501 LOC559501 dscama dscama ntng1a ntng1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ntn2Netrin 2. (609 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
A3KQ53_DANRENon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (423 aa)
sema3bSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (775 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
plxna4Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. (1903 aa)
sgk2bSerum/glucocorticoid-regulated kinase 2b; Belongs to the protein kinase superfamily. (404 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
sgk1Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (433 aa)
ntn1bNetrin 1b. (602 aa)
abl2Tyrosine-protein kinase. (1135 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
snai1bSnail family zinc finger 1b. (256 aa)
ctsbaCathepsin B, a; Belongs to the peptidase C1 family. (330 aa)
foxp3aForkhead box protein. (419 aa)
E7EXX6_DANRESi:dkey-202e22.2. (642 aa)
furinaFurin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (806 aa)
dscambDown syndrome cell adhesion molecule b. (2020 aa)
furinbFurin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (823 aa)
LOC100332721Neogenin 1b. (1413 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
ciitaClass II, major histocompatibility complex, transactivator. (1044 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
snai1aSnail family zinc finger 1a. (260 aa)
plxnd1Plexin D1. (398 aa)
plxnc1Plexin C1. (1056 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
mlst8Target of rapamycin complex subunit lst8. (326 aa)
rictorbRPTOR-independent companion of MTOR, complex 2b. (1698 aa)
plxnb1bPlexin b1b. (2220 aa)
ntn4Netrin 4. (639 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
unc5bUnc-5 netrin receptor B. (940 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
ntn1aNetrin-1a. (603 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
neo1aNeogenin 1a. (1428 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
unc5aUnc-5 netrin receptor A. (860 aa)
ctsbbCathepsin Bb; Belongs to the peptidase C1 family. (327 aa)
LOC559501Vav 3 guanine nucleotide exchange factor b. (471 aa)
dscamaDown syndrome cell adhesion molecule a. (2036 aa)
ntng1aNetrin g1a. (546 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.