STRINGSTRING
hhex hhex fgf17 fgf17 notch1a notch1a ctnnb1 ctnnb1 il17rd il17rd axin2 axin2 evx1 evx1 tbxta tbxta hoxc10a hoxc10a tbxtb tbxtb kat2a kat2a olig3 olig3 flt1 flt1 lft1 lft1 foxa2 foxa2 tbx4 tbx4 efna1b efna1b tbx6 tbx6 ctbp2a ctbp2a bmp7a bmp7a fgf8a fgf8a ptch1 ptch1 tbx3a tbx3a pou3f1 pou3f1 eno2 eno2 ets1 ets1 cyp26a1 cyp26a1 chrd chrd etv2 etv2 cited2 cited2 zeb1b zeb1b mnx1 mnx1 cxcl12a cxcl12a dennd2b dennd2b fgf8b fgf8b rspo3 rspo3 ctsh ctsh pou5f3 pou5f3 olig4 olig4 bmp4 bmp4 aldh1a2 aldh1a2 ptch2 ptch2 id2a id2a hoxd10a hoxd10a wnt3a wnt3a lin28a lin28a pdgfra pdgfra dvl1b dvl1b sox2 sox2 dusp6 dusp6 wnt4 wnt4 meox1 meox1 cdh5 cdh5 hoxc9a hoxc9a hoxc6a hoxc6a otx2b otx2b adora2b adora2b tbx16l tbx16l greb1 greb1 eno3 eno3 klf5b klf5b ENSDARP00000125042 ENSDARP00000125042 ccno ccno evx1-2 evx1-2 wnt5b wnt5b sox17 sox17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
fgf17Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family. (215 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
il17rdInterleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
evx1Even-skipped homeobox 1. (377 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
hoxc10aHomeobox C10a. (337 aa)
tbxtbT-box transcription factor Tb. (427 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
olig3Oligodendrocyte transcription factor 3. (255 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
tbx4T-box transcription factor 4. (543 aa)
efna1bEphrin A-L1; Belongs to the ephrin family. (229 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
ctbp2aC-terminal-binding protein 2a. (710 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
ptch1Protein patched homolog 1. (1475 aa)
tbx3aT-box transcription factor 3a. (689 aa)
pou3f1POU domain, class 3, transcription factor 1; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal; Belongs to the POU transcription factor family. Class-3 subfamily. (368 aa)
eno2Eno2 protein. (434 aa)
ets1V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
etv2ETS variant transcription factor 2. (366 aa)
cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2. (221 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
mnx1Motor neuron and pancreas homeobox 1. (311 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
dennd2bSuppression of tumorigenicity 5. (1132 aa)
fgf8bFibroblast growth factor 8b; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system. (212 aa)
rspo3R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and prunin [...] (317 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (330 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
olig4Oligodendrocyte transcription factor 4. (244 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
id2aInhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa)
hoxd10aHomeobox protein Hox-D10a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (332 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
lin28aProtein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (202 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
hoxc9aHomeobox protein Hox-C9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (270 aa)
hoxc6aHomeobox protein Hox-C6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (208 aa)
otx2bHomeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa)
adora2bAdenosine A2b receptor. (351 aa)
tbx16lT-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa)
greb1Growth-regulating estrogen receptor-binding 1. (1840 aa)
eno3Enolase 3, (beta, muscle). (433 aa)
klf5bKruppel-like factor 5b. (344 aa)
ENSDARP00000125042Patched 1. (120 aa)
ccnoCYCLIN domain-containing protein; Belongs to the cyclin family. (300 aa)
evx1-2Even-skipped homeobox 1. (252 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
sox17SRY-box transcription factor 17. (413 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.