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nfs1 nfs1 bud23 bud23 alkbh1 alkbh1 dph2 dph2 birc5a birc5a dek dek lef1 lef1 dph1 dph1 nsun2 nsun2 mettl1 mettl1 dph6 dph6 elp1 elp1 dph5 dph5 elp5 elp5 braf braf hif1aa hif1aa dnajc24 dnajc24 mocs3 mocs3 ctu1 ctu1 sod1 sod1 hif1ab hif1ab mmp9 mmp9 trmt6 trmt6 kti12 kti12 dph7 dph7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nfs1NFS1 nitrogen fixation 1 (S. cerevisiae). (451 aa)
bud23BUD23 rRNA methyltransferase and ribosome maturation factor. (282 aa)
alkbh1AlkB homolog 1, histone H2A dioxygenase. (331 aa)
dph22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). (498 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
dekDEK proto-oncogene. (443 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
dph12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Belongs to the DPH1/DPH2 family. DPH1 subfamily. (400 aa)
nsun2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (766 aa)
mettl1tRNA (guanine-N(7)-)-methyltransferase; Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)- methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs. (241 aa)
dph6Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). Belongs to the Diphthine--ammonia ligase family. (255 aa)
elp1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1311 aa)
dph5Diphthamide biosynthesis 5. (288 aa)
elp5Elongator complex protein 5; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP5 family. (296 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (817 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
dnajc24DnaJ (Hsp40) homolog, subfamily C, member 24. (149 aa)
mocs3Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (459 aa)
ctu1Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. (343 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
trmt6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (464 aa)
kti12Protein KTI12 homolog; Belongs to the KTI12 family. (275 aa)
dph7Diphthamide biosynthesis 7. (443 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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