STRINGSTRING
ada ada ccnd1 ccnd1 e2f1 e2f1 pxdn pxdn poc5 poc5 nck1b nck1b bcl2a bcl2a adgrg7.1 adgrg7.1 adgrg6 adgrg6 sp1 sp1 pgr pgr E7F1C0_DANRE E7F1C0_DANRE nck2a nck2a esr1 esr1 celsr2 celsr2 ctsd ctsd oxtrl oxtrl gapdh gapdh nck2b nck2b gapdhs gapdhs oxtr oxtr fosab fosab napsa napsa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (362 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
e2f1E2F transcription factor 1. (429 aa)
pxdnPeroxidasin. (1460 aa)
poc5POC5 centriolar protein homolog (Chlamydomonas). (567 aa)
nck1bCytoplasmic protein. (381 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
adgrg7.1Adhesion G protein-coupled receptor G7, tandem duplicate 1. (186 aa)
adgrg6Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa)
sp1Sp1 transcription factor. (594 aa)
pgrProgesterone receptor. (553 aa)
E7F1C0_DANRESi:dkey-178o16.4. (361 aa)
nck2aCytoplasmic protein. (403 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
celsr2Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2940 aa)
ctsdCtsd protein; Belongs to the peptidase A1 family. (398 aa)
oxtrlIsotocin receptor-like 1. (382 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
nck2bCytoplasmic protein. (380 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
oxtrIsotocin receptor-like 2; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (388 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
napsaNapsin A aspartic peptidase; Belongs to the peptidase A1 family. (412 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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