STRINGSTRING
actn3b actn3b fscn1b fscn1b src src LOC556989 LOC556989 TMC1 TMC1 ripor2 ripor2 fscn1a fscn1a fscn2a fscn2a scinlb scinlb twf2 twf2 acta1b acta1b dlg4 dlg4 gnai3 gnai3 gsnb gsnb capza1a capza1a scin scin dlg1 dlg1 gsna gsna cdh23 cdh23 gpsm2 gpsm2 fscn2b fscn2b cabp1a cabp1a myo3b myo3b pvalb2 pvalb2 myo7ab myo7ab tjp1a tjp1a ush1gb ush1gb myo7aa myo7aa lcp1 lcp1 FLNB FLNB capzb capzb scinla scinla eps8a eps8a cib2 cib2 eps8l2 eps8l2 espn espn espnlb espnlb whrnb whrnb myo3a myo3a tmie tmie whrna whrna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
fscn1bFascin. (494 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
LOC556989Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1124 aa)
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
fscn1aFascin. (491 aa)
fscn2aFascin. (488 aa)
scinlbScinderin-like b. (720 aa)
twf2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (347 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
gnai3Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3. (354 aa)
gsnbGelsolin b. (728 aa)
capza1aF-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
scinScinderin. (733 aa)
dlg1Disks large homolog 1; Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). May play a role in synapse assembly and function. Belongs to the MAGUK family. (909 aa)
gsnaGelsolin a. (729 aa)
cdh23Cadherin-related 23. (2883 aa)
gpsm2G protein-signaling modulator 2. (649 aa)
fscn2bFascin. (490 aa)
cabp1aCalcium-binding protein 1a. (186 aa)
myo3bMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
pvalb2Parvalbumin-2; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
myo7abMyosin VIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
lcp1Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells (By similarity). (624 aa)
FLNBFilamin B. (1992 aa)
capzbF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
scinlaScinderin-like a. (720 aa)
eps8aEpidermal growth factor receptor pathway substrate 8a. (804 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
eps8l2EPS8-like 2. (670 aa)
espnEspin. (873 aa)
espnlbEspin-like b. (1004 aa)
whrnbWhirlin b. (946 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
tmieTransmembrane inner ear. (231 aa)
whrnaWhirlin a. (939 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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