Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000125042 | arl13b | ENSDARP00000125042 | ENSDARP00000092960 | Patched 1. | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | 0.611 |
| ENSDARP00000125042 | ctnnb1 | ENSDARP00000125042 | ENSDARP00000139205 | Patched 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.575 |
| ENSDARP00000125042 | fgfr1a | ENSDARP00000125042 | ENSDARP00000013742 | Patched 1. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.430 |
| ENSDARP00000125042 | gli2a | ENSDARP00000125042 | ENSDARP00000010693 | Patched 1. | GLI family zinc finger 2a. | 0.959 |
| ENSDARP00000125042 | gli3 | ENSDARP00000125042 | ENSDARP00000058991 | Patched 1. | GLI family zinc finger 3. | 0.955 |
| ENSDARP00000125042 | gsk3ba | ENSDARP00000125042 | ENSDARP00000027785 | Patched 1. | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | 0.531 |
| ENSDARP00000125042 | ift80 | ENSDARP00000125042 | ENSDARP00000116409 | Patched 1. | Intraflagellar transport 80 homolog (Chlamydomonas). | 0.563 |
| ENSDARP00000125042 | ift88 | ENSDARP00000125042 | ENSDARP00000034047 | Patched 1. | Intraflagellar transport 88 homolog. | 0.705 |
| ENSDARP00000125042 | kif3a | ENSDARP00000125042 | ENSDARP00000107221 | Patched 1. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.608 |
| ENSDARP00000125042 | pdgfra | ENSDARP00000125042 | ENSDARP00000094286 | Patched 1. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] | 0.441 |
| ENSDARP00000125042 | pkd2 | ENSDARP00000125042 | ENSDARP00000027024 | Patched 1. | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] | 0.427 |
| ENSDARP00000125042 | prkacaa | ENSDARP00000125042 | ENSDARP00000135348 | Patched 1. | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. | 0.643 |
| ENSDARP00000125042 | prkacab | ENSDARP00000125042 | ENSDARP00000002825 | Patched 1. | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. | 0.644 |
| ENSDARP00000125042 | prkacba | ENSDARP00000125042 | ENSDARP00000023805 | Patched 1. | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. | 0.635 |
| ENSDARP00000125042 | prkacbb | ENSDARP00000125042 | ENSDARP00000076580 | Patched 1. | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. | 0.648 |
| ENSDARP00000125042 | shha | ENSDARP00000125042 | ENSDARP00000125090 | Patched 1. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.999 |
| ENSDARP00000125042 | shhb | ENSDARP00000125042 | ENSDARP00000056746 | Patched 1. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.996 |
| ENSDARP00000125042 | sufu | ENSDARP00000125042 | ENSDARP00000133214 | Patched 1. | Suppressor of fused homolog. | 0.938 |
| ENSDARP00000125042 | talpid3 | ENSDARP00000125042 | ENSDARP00000131742 | Patched 1. | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. | 0.492 |
| ENSDARP00000135075 | egf | ENSDARP00000135075 | ENSDARP00000069126 | Platelet-derived growth factor alpha polypeptide a. | Epidermal growth factor. | 0.484 |
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