Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| atg9a | becn1 | ENSDARP00000065410 | ENSDARP00000100986 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.915 |
| becn1 | atg9a | ENSDARP00000100986 | ENSDARP00000065410 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.915 |
| becn1 | casp3a | ENSDARP00000100986 | ENSDARP00000006831 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | 0.850 |
| becn1 | casp3b | ENSDARP00000100986 | ENSDARP00000071815 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. | 0.850 |
| becn1 | foxo3a | ENSDARP00000100986 | ENSDARP00000036177 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Forkhead box O3A. | 0.609 |
| becn1 | sirt3 | ENSDARP00000100986 | ENSDARP00000051972 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.492 |
| becn1 | tp53 | ENSDARP00000100986 | ENSDARP00000116736 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.787 |
| casp3a | becn1 | ENSDARP00000006831 | ENSDARP00000100986 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.850 |
| casp3a | casp3b | ENSDARP00000006831 | ENSDARP00000071815 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. | 0.903 |
| casp3a | ccn2a | ENSDARP00000006831 | ENSDARP00000063027 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | 0.402 |
| casp3a | cdh2 | ENSDARP00000006831 | ENSDARP00000003949 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.554 |
| casp3a | edn1 | ENSDARP00000006831 | ENSDARP00000095917 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Endothelin 1. | 0.409 |
| casp3a | foxo3a | ENSDARP00000006831 | ENSDARP00000036177 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Forkhead box O3A. | 0.527 |
| casp3a | itgam | ENSDARP00000006831 | ENSDARP00000133914 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Integrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. | 0.554 |
| casp3a | smad2 | ENSDARP00000006831 | ENSDARP00000106756 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | 0.485 |
| casp3a | tgfb1a | ENSDARP00000006831 | ENSDARP00000060838 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.450 |
| casp3a | tp53 | ENSDARP00000006831 | ENSDARP00000116736 | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.964 |
| casp3b | becn1 | ENSDARP00000071815 | ENSDARP00000100986 | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.850 |
| casp3b | casp3a | ENSDARP00000071815 | ENSDARP00000006831 | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | 0.903 |
| casp3b | cdh2 | ENSDARP00000071815 | ENSDARP00000003949 | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.541 |
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