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nbr1b nbr1b vps35 vps35 C13H9orf72 C13H9orf72 casp3a casp3a hsp70.3 hsp70.3 bdnf bdnf vcp vcp mapk8b mapk8b ATG14 ATG14 pink1 pink1 dvl2 dvl2 baxa baxa gsk3ba gsk3ba uchl1 uchl1 bnip3la bnip3la traf6 traf6 bnip3lb bnip3lb tp53inp1 tp53inp1 ptk2ab ptk2ab rab1ab rab1ab ins ins atg13 atg13 map2k5 map2k5 ttr ttr cul3a cul3a tardbp tardbp nfe2l2a nfe2l2a atg101 atg101 sod1 sod1 gsk3bb gsk3bb htt htt casp3b casp3b map3k3 map3k3 pik3r4 pik3r4 atp13a2 atp13a2 pik3c3 pik3c3 atg12 atg12 mapk3 mapk3 becn1 becn1 tnfrsf11a tnfrsf11a hsp70.1 hsp70.1 insb insb sqstm1 sqstm1 traf5 traf5 stub1 stub1 bcl2a bcl2a nbr1a nbr1a atg5 atg5 hdac6 hdac6 LOC100004321 LOC100004321 ulk2 ulk2 akt1 akt1 cul3b cul3b tpcn2 tpcn2 atg7 atg7 psen1 psen1 zgc:153993 zgc:153993 bnip3 bnip3 atg10 atg10 prkn prkn mapk8a mapk8a enc1 enc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nbr1bNBR1 autophagy cargo receptor b. (992 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (831 aa)
C13H9orf72Zgc:100846. (462 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
ATG14Zgc:113944. (517 aa)
pink1PTEN-induced kinase 1. (574 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
uchl1Ubiquitin carboxyl-terminal hydrolase. (218 aa)
bnip3laBCL2/adenovirus E1B interacting protein 3-like, 2. (233 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
bnip3lbBCL2-interacting protein 3-like b. (213 aa)
tp53inp1Tumor protein p53-inducible nuclear protein 1. (241 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
rab1abRAB1A, member RAS oncogene family b. (201 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
atg13Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (450 aa)
ttrTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (149 aa)
cul3aCullin 3a; Belongs to the cullin family. (774 aa)
tardbpTAR DNA-binding protein. (412 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
atg101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
httHuntingtin. (3121 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
map3k3Mitogen-activated protein kinase kinase kinase 3. (626 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1347 aa)
atp13a2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1170 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
sqstm1Sequestosome 1. (452 aa)
traf5Tnf receptor-associated factor 5. (305 aa)
stub1STIP1 homology and U-Box-containing protein 1. (287 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
nbr1aNBR1 autophagy cargo receptor a. (989 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
hdac6Histone deacetylase 6. (1081 aa)
LOC100004321BCL2-associated X, apoptosis regulator a. (197 aa)
ulk2Unc-51-like autophagy-activating kinase 2. (1034 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
tpcn2Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity). (774 aa)
atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (711 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
zgc:153993Zgc:153993 protein. (204 aa)
bnip3BCL2-interacting protein 3. (183 aa)
atg10ATG10 autophagy-related 10 homolog (S. cerevisiae). (224 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
mapk8aMitogen-activated protein kinase. (427 aa)
enc1Ectodermal-neural cortex 1. (591 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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