STRINGSTRING
pax5 pax5 cd44a cd44a bmi1a bmi1a bcl11aa bcl11aa ikzf1 ikzf1 spi1b spi1b cxcr5 cxcr5 hoxb4a hoxb4a rnf2 rnf2 ebf1b ebf1b kdrl kdrl itgam itgam ccr7 ccr7 lmo2 lmo2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pax5Paired box 5. (396 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
bmi1aPolycomb complex protein BMI-1-A; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2. (322 aa)
bcl11aaBAF chromatin-remodeling complex subunit BCL11A a. (829 aa)
ikzf1IKAROS family zinc finger 1 (Ikaros). (526 aa)
spi1bSI:bY184L24.2.1 (Transcription factor spi1). (296 aa)
cxcr5Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (378 aa)
hoxb4aHomeobox protein Hox-B4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (246 aa)
rnf2E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa)
ebf1bEBF transcription factor 1b. (603 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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