STRINGSTRING
fgf9 fgf9 tet1 tet1 notch1a notch1a pax7a pax7a evx1 evx1 tbxta tbxta tet3 tet3 tbxtb tbxtb zbtb16a zbtb16a nanos2 nanos2 nr0b1 nr0b1 neurog3 neurog3 hist1h2a2 hist1h2a2 bmi1a bmi1a figla figla etv5a etv5a dmrt1 dmrt1 prdm14 prdm14 dazl dazl LOC108192159 LOC108192159 fsta fsta gdnfa gdnfa msh4 msh4 X1WHF1_DANRE X1WHF1_DANRE fgf2 fgf2 evx1-2 evx1-2 foxo1a foxo1a spo11 spo11 acvr1l acvr1l inhbaa inhbaa casp3a casp3a map2k1 map2k1 gdf9 gdf9 atm atm amh amh fgf8a fgf8a lhx1a lhx1a sycp3 sycp3 prdm9 prdm9 pou3f1 pou3f1 lhx8a lhx8a six1b six1b ifnphi1 ifnphi1 h2ax h2ax smad5 smad5 bmp15 bmp15 lhx9 lhx9 hist2h2l hist2h2l emx2 emx2 inhbb inhbb cx43 cx43 cxcr4b cxcr4b foxl2a foxl2a sall4 sall4 pou5f3 pou5f3 id4 id4 egf egf bmp4 bmp4 casp3b casp3b dmc1 dmc1 ptenb ptenb fstb fstb prmt5 prmt5 lin28a lin28a bcl6b bcl6b hist1h2a3 hist1h2a3 wnt4 wnt4 smad4a smad4a kita kita tet2 tet2 cyp26b1 cyp26b1 hoxb1a hoxb1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
tet1Tet methylcytosine dioxygenase 1. (1855 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
pax7aTranscription factor PAX7C. (507 aa)
evx1Even-skipped homeobox 1. (377 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
tet3Tet methylcytosine dioxygenase 3. (2052 aa)
tbxtbT-box transcription factor Tb. (427 aa)
zbtb16aZinc finger and BTB domain-containing protein 16-A; Probable transcription factor. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis. Belongs to the krueppel C2H2-type zinc-finger protein family. (671 aa)
nanos2Nanos homolog 2; Belongs to the nanos family. (146 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
neurog3Neurog3 protein. (208 aa)
hist1h2a2Histone cluster 1 H2A family member 2. (128 aa)
bmi1aPolycomb complex protein BMI-1-A; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2. (322 aa)
figlaFolliculogenesis-specific bHLH transcription factor. (220 aa)
etv5aETS variant transcription factor 5a. (524 aa)
dmrt1Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity); Belongs to the DMRT family. (268 aa)
prdm14PR domain-containing 14. (568 aa)
dazlDeleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). (229 aa)
LOC108192159REC8 meiotic recombination protein a. (460 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
gdnfaGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa)
msh4MutS homolog 4. (931 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
evx1-2Even-skipped homeobox 1. (252 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (383 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
inhbaaInhibin subunit beta Aa. (395 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
gdf9Growth differentiation factor 9. (418 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
amhAnti-Mullerian hormone. (549 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
lhx1aLIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa)
sycp3Synaptonemal complex protein 3 like. (240 aa)
prdm9Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] (853 aa)
pou3f1POU domain, class 3, transcription factor 1; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal; Belongs to the POU transcription factor family. Class-3 subfamily. (368 aa)
lhx8aLIM homeobox 8a. (332 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
ifnphi1Interferon phi 1. (185 aa)
h2axHistone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] (142 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
bmp15Bone morphogenetic protein 15. (384 aa)
lhx9LIM/homeobox protein Lhx9; May be involved in gonadal development. (396 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
emx2Empty spiracles homeobox 2. (247 aa)
inhbbInhibin subunit beta B. (393 aa)
cx43Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
foxl2aForkhead box L2-1. (306 aa)
sall4Spalt-like transcription factor 4. (1091 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
id4Inhibitor of DNA-binding 4. (126 aa)
egfEpidermal growth factor. (1114 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
fstbFollistatin 2. (344 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
lin28aProtein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (202 aa)
bcl6bBCL6B transcription repressor. (550 aa)
hist1h2a3Histone H2A; Belongs to the histone H2A family. (128 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
tet2Tet methylcytosine dioxygenase 2. (1715 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
hoxb1aHomeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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