STRINGSTRING
ddx1 ddx1 lmna lmna RANBP2 RANBP2 EML4 EML4 bard1 bard1 cdkn2a/b cdkn2a/b strn strn lmo1 lmo1 numa1 numa1 phox2bb phox2bb nf1a nf1a hip1 hip1 tpm3 tpm3 egfra egfra myh9a myh9a alk alk prkar1aa prkar1aa mapk7 mapk7 ptpn3 ptpn3 ros1 ros1 tp53 tp53 fn1a fn1a atrx atrx mtor mtor sec31a sec31a lin28b lin28b kita kita traf1 traf1 cdk4 cdk4 erbb4a erbb4a mdm2 mdm2 cltca cltca ltk ltk chek2 chek2 tpm4a tpm4a mycn mycn atic atic bmpr1aa bmpr1aa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ddx1DEAD (Asp-Glu-Ala-Asp) box helicase 1. (740 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
RANBP2Si:ch1073-55a19.2. (2953 aa)
EML4EMAP like 4. (956 aa)
bard1BRCA1-associated RING domain 1. (687 aa)
cdkn2a/bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa)
strnStriatin, calmodulin-binding protein. (782 aa)
lmo1Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. (175 aa)
numa1Wu:fb44b02. (2450 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
nf1aNeurofibromin 1a. (2759 aa)
hip1Huntingtin-interacting protein 1. (1046 aa)
tpm3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
alkTyrosine-protein kinase receptor. (1181 aa)
prkar1aaProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) a. (379 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1080 aa)
ptpn3Protein tyrosine phosphatase non-receptor type 3. (839 aa)
ros1Tyrosine-protein kinase receptor. (1289 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
fn1aFibronectin 1a. (2480 aa)
atrxATRX chromatin remodeler. (2013 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
sec31aProtein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1250 aa)
lin28bLin-28 homolog B (C. elegans). (210 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
traf1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (297 aa)
erbb4aReceptor protein-tyrosine kinase. (1388 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. (475 aa)
cltcaClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
ltkTyrosine-protein kinase receptor. (1530 aa)
chek2Checkpoint kinase 2. (503 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (590 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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