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vcla vcla foxd3 foxd3 notch1a notch1a elp1 elp1 fgf2 fgf2 phox2bb phox2bb chd7 chd7 pax3a pax3a twist1a twist1a snai2 snai2 bmp4 bmp4 mef2ca mef2ca sox10 sox10 vclb vclb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vclaVinculin a. (1131 aa)
foxd3Forkhead box D3. (371 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
elp1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1311 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
pax3aTranscription factor PAX3. (509 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
vclbVinculin b. (987 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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