(9 nodes) (2019) Modelling Protein Synthesis as A Biomarker in Fragile X Syndrome Patient-Derived Cells. network (Danio rerio)

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Your Input:
	eif4e1b	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein. (214 aa)
	cyfip1	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family. (1253 aa)
	mapk3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
	foxg1a	Forkhead box G1a. (420 aa)
	eif4ea	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (215 aa)
	fmr1	FMRP translational regulator 1. (569 aa)
	eef2b	Eukaryotic translation elongation factor 2, like. (858 aa)
	grm5b	Glutamate receptor, metabotropic 5b. (1195 aa)
	grm5a	Glutamate receptor, metabotropic 5a. (1173 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cyfip1	eif4e1b	ENSDARP00000065126	ENSDARP00000022906	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	0.989
cyfip1	eif4ea	ENSDARP00000065126	ENSDARP00000103599	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	0.989
cyfip1	fmr1	ENSDARP00000065126	ENSDARP00000104665	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	FMRP translational regulator 1.	0.996
cyfip1	mapk3	ENSDARP00000065126	ENSDARP00000094521	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.447
eef2b	eif4e1b	ENSDARP00000131100	ENSDARP00000022906	Eukaryotic translation elongation factor 2, like.	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	0.662
eef2b	eif4ea	ENSDARP00000131100	ENSDARP00000103599	Eukaryotic translation elongation factor 2, like.	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	0.662
eif4e1b	cyfip1	ENSDARP00000022906	ENSDARP00000065126	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	0.989
eif4e1b	eef2b	ENSDARP00000022906	ENSDARP00000131100	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	Eukaryotic translation elongation factor 2, like.	0.662
eif4e1b	eif4ea	ENSDARP00000022906	ENSDARP00000103599	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	0.726
eif4e1b	fmr1	ENSDARP00000022906	ENSDARP00000104665	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	FMRP translational regulator 1.	0.728
eif4ea	cyfip1	ENSDARP00000103599	ENSDARP00000065126	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	0.989
eif4ea	eef2b	ENSDARP00000103599	ENSDARP00000131100	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	Eukaryotic translation elongation factor 2, like.	0.662
eif4ea	eif4e1b	ENSDARP00000103599	ENSDARP00000022906	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	0.726
eif4ea	fmr1	ENSDARP00000103599	ENSDARP00000104665	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	FMRP translational regulator 1.	0.736
fmr1	cyfip1	ENSDARP00000104665	ENSDARP00000065126	FMRP translational regulator 1.	Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.	0.996
fmr1	eif4e1b	ENSDARP00000104665	ENSDARP00000022906	FMRP translational regulator 1.	Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein.	0.728
fmr1	eif4ea	ENSDARP00000104665	ENSDARP00000103599	FMRP translational regulator 1.	Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.	0.736
fmr1	grm5a	ENSDARP00000104665	ENSDARP00000145421	FMRP translational regulator 1.	Glutamate receptor, metabotropic 5a.	0.468
fmr1	grm5b	ENSDARP00000104665	ENSDARP00000131878	FMRP translational regulator 1.	Glutamate receptor, metabotropic 5b.	0.482
grm5a	fmr1	ENSDARP00000145421	ENSDARP00000104665	Glutamate receptor, metabotropic 5a.	FMRP translational regulator 1.	0.468

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