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casp3b casp3b ctnnb1 ctnnb1 dusp16 dusp16 dusp1 dusp1 dusp7 dusp7 phox2bb phox2bb nf1a nf1a egfra egfra odc1 odc1 ptprja ptprja alk alk mapk7 mapk7 tp53 tp53 dusp13a dusp13a mtor mtor dusp12 dusp12 dusp6 dusp6 casp3a casp3a map2k1 map2k1 bdnf bdnf fgfr1a fgfr1a cdh2 cdh2 ntrk1 ntrk1 trh trh mycn mycn styx styx styxl1 styxl1 ptk2ab ptk2ab map3k5 map3k5 nras nras dusp4 dusp4 dusp10 dusp10 egf egf mapk3 mapk3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
dusp16Dual-specificity phosphatase 16. (539 aa)
dusp1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (374 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
nf1aNeurofibromin 1a. (2759 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
odc1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
ptprjaProtein tyrosine phosphatase receptor type Ja. (1650 aa)
alkTyrosine-protein kinase receptor. (1181 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1080 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
dusp13aDual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (189 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
dusp12Dual-specificity phosphatase 12. (305 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
ntrk1Tyrosine-protein kinase receptor. (797 aa)
trhPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (199 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
styxSerine/threonine/tyrosine-interacting protein. (224 aa)
styxl1Serine/threonine/tyrosine-interacting-like 1. (295 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
map3k5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
dusp10Dual-specificity phosphatase 10. (459 aa)
egfEpidermal growth factor. (1114 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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