Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000125042 | axin2 | ENSDARP00000125042 | ENSDARP00000132477 | Patched 1. | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | 0.533 |
| ENSDARP00000125042 | ctnnb1 | ENSDARP00000125042 | ENSDARP00000139205 | Patched 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.575 |
| ENSDARP00000125042 | dhh | ENSDARP00000125042 | ENSDARP00000053870 | Patched 1. | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. | 0.981 |
| ENSDARP00000125042 | gli1 | ENSDARP00000125042 | ENSDARP00000129932 | Patched 1. | GLI family zinc finger 1. | 0.961 |
| ENSDARP00000125042 | gli2a | ENSDARP00000125042 | ENSDARP00000010693 | Patched 1. | GLI family zinc finger 2a. | 0.959 |
| ENSDARP00000125042 | gli3 | ENSDARP00000125042 | ENSDARP00000058991 | Patched 1. | GLI family zinc finger 3. | 0.955 |
| ENSDARP00000125042 | gpr161 | ENSDARP00000125042 | ENSDARP00000072514 | Patched 1. | G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] | 0.667 |
| ENSDARP00000125042 | gsk3ba | ENSDARP00000125042 | ENSDARP00000027785 | Patched 1. | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | 0.531 |
| ENSDARP00000125042 | ift172 | ENSDARP00000125042 | ENSDARP00000061333 | Patched 1. | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | 0.595 |
| ENSDARP00000125042 | ift27 | ENSDARP00000125042 | ENSDARP00000131706 | Patched 1. | Intraflagellar transport 27 homolog (Chlamydomonas). | 0.472 |
| ENSDARP00000125042 | ift88 | ENSDARP00000125042 | ENSDARP00000034047 | Patched 1. | Intraflagellar transport 88 homolog. | 0.705 |
| ENSDARP00000125042 | ihhb | ENSDARP00000125042 | ENSDARP00000076199 | Patched 1. | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. | 0.992 |
| ENSDARP00000125042 | kif3a | ENSDARP00000125042 | ENSDARP00000107221 | Patched 1. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.608 |
| ENSDARP00000125042 | kif7 | ENSDARP00000125042 | ENSDARP00000041576 | Patched 1. | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. | 0.808 |
| ENSDARP00000125042 | pdgfra | ENSDARP00000125042 | ENSDARP00000094286 | Patched 1. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] | 0.441 |
| ENSDARP00000125042 | smo | ENSDARP00000125042 | ENSDARP00000013486 | Patched 1. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.996 |
| ENSDARP00000125042 | sufu | ENSDARP00000125042 | ENSDARP00000133214 | Patched 1. | Suppressor of fused homolog. | 0.938 |
| SDHB | fh | ENSDARP00000118231 | ENSDARP00000097494 | Si:dkey-31b16.7. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] | 0.918 |
| ahi1 | ctnnb1 | ENSDARP00000124018 | ENSDARP00000139205 | Abelson helper integration site 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.688 |
| ahi1 | gli3 | ENSDARP00000124018 | ENSDARP00000058991 | Abelson helper integration site 1. | GLI family zinc finger 3. | 0.433 |
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