STRINGSTRING
mtor mtor vcla vcla numbl numbl X1WHF1_DANRE X1WHF1_DANRE tgfb1b tgfb1b calcr calcr notch2 notch2 myf5 myf5 prdm16 prdm16 actn3b actn3b dmd dmd cdc25b cdc25b myod1 myod1 myog myog twist3 twist3 tnfb tnfb wnt7ba wnt7ba tgfb3 tgfb3 pax3a pax3a myf6 myf6 hist2h2l hist2h2l dek dek tgfb1a tgfb1a cxcr4b cxcr4b wnt7aa wnt7aa ccnd2a ccnd2a notch3 notch3 srfa srfa wnt1 wnt1 cxcr4a cxcr4a sdc4 sdc4 pxnb pxnb drosha drosha wnt3a wnt3a numb numb pdgfra pdgfra wnt4 wnt4 tgfb5 tgfb5 il10 il10 kl kl vclb vclb twist2 twist2 tln2b tln2b pxna pxna vcam1b vcam1b ctnnb1 ctnnb1 hdac4 hdac4 pax7a pax7a notch1a notch1a wnt5a wnt5a spry1 spry1 wnt5b wnt5b tln2a tln2a fgf2 fgf2 tln1 tln1 Sdc3 Sdc3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
vclaVinculin a. (1131 aa)
numblNUMB-like endocytic adaptor protein. (618 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
calcrCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (598 aa)
notch2Notch receptor 2. (2475 aa)
myf5Myogenic factor. (237 aa)
prdm16Si:ch211-263k4.2. (927 aa)
actn3bActinin alpha 3b. (898 aa)
dmdDystrophin. (594 aa)
cdc25bCell division cycle 25B. (563 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
twist3Twist3. (199 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
wnt7baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
pax3aTranscription factor PAX3. (509 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
dekDEK proto-oncogene. (443 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
wnt7aaProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ccnd2aCyclin D2, a; Belongs to the cyclin family. (298 aa)
notch3Notch receptor 3. (2468 aa)
srfaSerum response factor a. (539 aa)
wnt1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
cxcr4aChemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
sdc4Syndecan 4. (207 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
droshaDrosha ribonuclease III. (1289 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
numbNUMB endocytic adaptor protein. (680 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
il10Interleukin-10. (180 aa)
klKlotho. (990 aa)
vclbVinculin b. (987 aa)
twist2Twist2. (163 aa)
tln2bTalin 2b. (1537 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
pax7aTranscription factor PAX7C. (507 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
spry1Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). (292 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
tln2aTalin 2a. (2543 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
tln1Talin 1. (2544 aa)
Sdc3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (436 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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