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zic2a zic2a prkacab prkacab gli2a gli2a smo smo bmp2a bmp2a fgf8a fgf8a prkacba prkacba ptch1 ptch1 ift88 ift88 cyp26a1 cyp26a1 zic2b zic2b scube2 scube2 shhb shhb ift172 ift172 egf egf six3b six3b ptch2 ptch2 six3a six3a ihhb ihhb prkacbb prkacbb tgif1 tgif1 rpgrip1l rpgrip1l kif3a kif3a bmp2b bmp2b ENSDARP00000125042 ENSDARP00000125042 shha shha lrp2a lrp2a talpid3 talpid3 sufu sufu prkacaa prkacaa cdo1 cdo1 DYNC2H1 DYNC2H1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
zic2aZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
ptch1Protein patched homolog 1. (1475 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
zic2bZIC family member 2 (Odd-paired homolog, Drosophila) B. (427 aa)
scube2Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
egfEpidermal growth factor. (1114 aa)
six3bSine oculis homeobox homolog 3b. (293 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
six3aSine oculis homeobox homolog 3a. (294 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
tgif1TGFB-induced factor homeobox 1. (273 aa)
rpgrip1lRPGRIP1-like. (1256 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
talpid3Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa)
sufuSuppressor of fused homolog. (485 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
cdo1Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. (203 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4208 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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