node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000145932 | atf6 | ENSDARP00000145932 | ENSDARP00000009333 | TORC_N domain-containing protein. | Activating transcription factor 6. | 0.432 |
atf3 | atf6 | ENSDARP00000027550 | ENSDARP00000009333 | Activating transcription factor 3. | Activating transcription factor 6. | 0.673 |
atf3 | il1b | ENSDARP00000027550 | ENSDARP00000140751 | Activating transcription factor 3. | Interleukin-1. | 0.597 |
atf3 | jun | ENSDARP00000027550 | ENSDARP00000063911 | Activating transcription factor 3. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.988 |
atf3 | sesn2 | ENSDARP00000027550 | ENSDARP00000093160 | Activating transcription factor 3. | Sestrin 2. | 0.567 |
atf3 | tnfb | ENSDARP00000027550 | ENSDARP00000010728 | Activating transcription factor 3. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.463 |
atf3 | tp53 | ENSDARP00000027550 | ENSDARP00000116736 | Activating transcription factor 3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.878 |
atf6 | ENSDARP00000145932 | ENSDARP00000009333 | ENSDARP00000145932 | Activating transcription factor 6. | TORC_N domain-containing protein. | 0.432 |
atf6 | atf3 | ENSDARP00000009333 | ENSDARP00000027550 | Activating transcription factor 6. | Activating transcription factor 3. | 0.673 |
atf6 | crtc2 | ENSDARP00000009333 | ENSDARP00000101990 | Activating transcription factor 6. | CREB-regulated transcription coactivator 2. | 0.547 |
atf6 | ins | ENSDARP00000009333 | ENSDARP00000051221 | Activating transcription factor 6. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.482 |
atf6 | insb | ENSDARP00000009333 | ENSDARP00000115146 | Activating transcription factor 6. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.432 |
atf6 | jun | ENSDARP00000009333 | ENSDARP00000063911 | Activating transcription factor 6. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.624 |
atf6 | nfe2l2a | ENSDARP00000009333 | ENSDARP00000062853 | Activating transcription factor 6. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.499 |
atf6 | tp53 | ENSDARP00000009333 | ENSDARP00000116736 | Activating transcription factor 6. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.455 |
crtc2 | atf6 | ENSDARP00000101990 | ENSDARP00000009333 | CREB-regulated transcription coactivator 2. | Activating transcription factor 6. | 0.547 |
ddit4 | tp53 | ENSDARP00000127401 | ENSDARP00000116736 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.547 |
fgf21 | il1b | ENSDARP00000140850 | ENSDARP00000140751 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Interleukin-1. | 0.451 |
fgf21 | ins | ENSDARP00000140850 | ENSDARP00000051221 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.794 |
fgf21 | insb | ENSDARP00000140850 | ENSDARP00000115146 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.793 |