STRINGSTRING
jun jun fgf21 fgf21 il1b il1b ddit4 ddit4 vcam1b vcam1b tp53 tp53 insb insb crtc2 crtc2 il10 il10 insrb insrb mif mif sesn2 sesn2 nfe2l2a nfe2l2a ins ins hmox1a hmox1a atf3 atf3 insra insra tnfb tnfb atf6 atf6 ENSDARP00000145932 ENSDARP00000145932 TCF4 TCF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
fgf21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (194 aa)
il1bInterleukin-1. (284 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
crtc2CREB-regulated transcription coactivator 2. (759 aa)
il10Interleukin-10. (180 aa)
insrbTyrosine-protein kinase receptor. (1348 aa)
mifMacrophage migration inhibitory factor. (115 aa)
sesn2Sestrin 2. (444 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
hmox1aHeme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (272 aa)
atf3Activating transcription factor 3. (202 aa)
insraTyrosine-protein kinase receptor. (1353 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
atf6Activating transcription factor 6. (653 aa)
ENSDARP00000145932TORC_N domain-containing protein. (72 aa)
TCF4Transcription factor 4. (536 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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