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aurkb aurkb pfn2l pfn2l cd81a cd81a plk4 plk4 wasb wasb daam1a daam1a cfl1 cfl1 dvl2 dvl2 rhoab rhoab nedd1 nedd1 prickle2a prickle2a wnt11f2 wnt11f2 wasa wasa aurka aurka cfl1l cfl1l cfl2 cfl2 daam2 daam2 fzd6 fzd6 cetn2 cetn2 prickle2b prickle2b pxdn pxdn cdc42 cdc42 X1WCU6_DANRE X1WCU6_DANRE pcnt pcnt prickle1b prickle1b nubp2 nubp2 pfn1 pfn1 pfn2 pfn2 wnt11 wnt11 spire1a spire1a gapdh gapdh cetn4 cetn4 prickle1a prickle1a acta1b acta1b gapdhs gapdhs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (320 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
cd81aTetraspanin. (236 aa)
plk4Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] (941 aa)
wasbWASP actin nucleation-promoting factor b. (479 aa)
daam1aDishevelled-associated activator of morphogenesis 1a. (1084 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
nedd1NEDD1 gamma-tubulin ring complex targeting factor. (677 aa)
prickle2aPrickle homolog 2a. (869 aa)
wnt11f2Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa)
wasaWASP actin nucleation-promoting factor a. (630 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
daam2Dishevelled-associated activator of morphogenesis 2. (1089 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa)
cetn2Centrin, EF-hand protein, 2. (172 aa)
prickle2bPrickle homolog 2b. (840 aa)
pxdnPeroxidasin. (1460 aa)
cdc42Cell division cycle 42. (191 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
pcntPericentrin. (4245 aa)
prickle1bPrickle homolog 1b. (863 aa)
nubp2Cytosolic Fe-S cluster assembly factor nubp2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (269 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
spire1aProtein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with fmn2, promotes assembly of nuclear actin filaments in [...] (761 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
cetn4Centrin 4. (171 aa)
prickle1aPrickle homolog 1a. (793 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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