STRINGSTRING
notch1a notch1a mmp2 mmp2 oclna oclna gli2a gli2a tnfb tnfb anxa2a anxa2a rhoab rhoab foxf1 foxf1 baxa baxa ptch1 ptch1 mycn mycn bcl2l1 bcl2l1 ntn1b ntn1b kif7 kif7 angpt1 angpt1 kdr kdr ins ins scube2 scube2 tek tek klf17 klf17 shhb shhb anxa2b anxa2b gli3 gli3 tgfb1a tgfb1a mmp9 mmp9 disp1 disp1 notch3 notch3 bmp4 bmp4 angpt2b angpt2b ptch2 ptch2 ihha ihha ihhb ihhb hhip hhip cdon cdon gas1b gas1b nrp1b nrp1b vegfc vegfc mapk3 mapk3 klf4 klf4 f11r.1 f11r.1 fgf9 fgf9 cdh5 cdh5 dzip1 dzip1 insb insb eya1 eya1 calcrla calcrla bcl2a bcl2a vegfd vegfd tgfb1b tgfb1b hhat hhat ENSDARP00000125042 ENSDARP00000125042 shha shha ntn2 ntn2 talpid3 talpid3 sufu sufu flt4 flt4 vegfaa vegfaa ntn1a ntn1a zgc:101785 zgc:101785 e2f1 e2f1 ctnnb1 ctnnb1 tymp tymp angpt2a angpt2a ccnd1 ccnd1 il1b il1b nrp1a nrp1a gas1a gas1a vcam1b vcam1b pdgfbb pdgfbb angpt4 angpt4 tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
oclnaOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (491 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
anxa2aAnnexin. (337 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
foxf1Forkhead box protein F1. (380 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
ptch1Protein patched homolog 1. (1475 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
ntn1bNetrin 1b. (602 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
angpt1Angiopoietin 1. (513 aa)
kdrVascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
scube2Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
tekTyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)
klf17Kruppel-like factor 17. (409 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
anxa2bAnnexin. (338 aa)
gli3GLI family zinc finger 3. (1553 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
notch3Notch receptor 3. (2468 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
angpt2bAngiopoietin 2b. (489 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
hhipHedgehog-interacting protein. (693 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
gas1bGrowth arrest-specific 1b. (263 aa)
nrp1bNeuropilin 1b. (540 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
klf4Kruppel-like factor 4. (340 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
dzip1Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
calcrlaCalcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity); Belongs to the G-protein coupled receptor 2 family. (474 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
hhatHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (508 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ntn2Netrin 2. (609 aa)
talpid3Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa)
sufuSuppressor of fused homolog. (485 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
ntn1aNetrin-1a. (603 aa)
zgc:101785Annexin. (326 aa)
e2f1E2F transcription factor 1. (429 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
tympThymidine phosphorylase. (146 aa)
angpt2aAngiopoietin 2a. (488 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
il1bInterleukin-1. (284 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
gas1aGrowth arrest-specific 1a. (270 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
angpt4Angiopoietin 4. (499 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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