17 items (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	tnnt1	Troponin T type 1 (skeletal, slow). (342 aa)
	sox6	SRY-box transcription factor 6. (816 aa)
	erbb2	Receptor protein-tyrosine kinase. (1275 aa)
	igf1	Insulin-like growth factor 1b. (161 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	tnnt2c	Troponin T1, skeletal, slow. (290 aa)
	ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	scube2	Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
	egf	Epidermal growth factor. (1114 aa)
	mylpfa	Myosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
	ucp3	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	insb	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
	egfra	Epidermal growth factor receptor precursor. (625 aa)
	cs	Citrate synthase, mitochondrial. (468 aa)
	smyhc1	Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
	hrasa	HRas proto-oncogene, GTPase a. (189 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
egf	egfra	ENSDARP00000069126	ENSDARP00000125265	Epidermal growth factor.	Epidermal growth factor receptor precursor.	0.999
egf	erbb2	ENSDARP00000069126	ENSDARP00000010252	Epidermal growth factor.	Receptor protein-tyrosine kinase.	0.977
egf	ins	ENSDARP00000069126	ENSDARP00000051221	Epidermal growth factor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.975
egf	insb	ENSDARP00000069126	ENSDARP00000115146	Epidermal growth factor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.961
egfra	egf	ENSDARP00000125265	ENSDARP00000069126	Epidermal growth factor receptor precursor.	Epidermal growth factor.	0.999
egfra	eif2ak3	ENSDARP00000125265	ENSDARP00000120826	Epidermal growth factor receptor precursor.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.434
egfra	erbb2	ENSDARP00000125265	ENSDARP00000010252	Epidermal growth factor receptor precursor.	Receptor protein-tyrosine kinase.	0.938
egfra	hrasa	ENSDARP00000125265	ENSDARP00000142010	Epidermal growth factor receptor precursor.	HRas proto-oncogene, GTPase a.	0.664
egfra	igf1	ENSDARP00000125265	ENSDARP00000017449	Epidermal growth factor receptor precursor.	Insulin-like growth factor 1b.	0.722
egfra	ins	ENSDARP00000125265	ENSDARP00000051221	Epidermal growth factor receptor precursor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.967
egfra	insb	ENSDARP00000125265	ENSDARP00000115146	Epidermal growth factor receptor precursor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.967
eif2ak3	egfra	ENSDARP00000120826	ENSDARP00000125265	Eukaryotic translation initiation factor 2-alpha kinase 3.	Epidermal growth factor receptor precursor.	0.434
eif2ak3	ins	ENSDARP00000120826	ENSDARP00000051221	Eukaryotic translation initiation factor 2-alpha kinase 3.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.460
erbb2	egf	ENSDARP00000010252	ENSDARP00000069126	Receptor protein-tyrosine kinase.	Epidermal growth factor.	0.977
erbb2	egfra	ENSDARP00000010252	ENSDARP00000125265	Receptor protein-tyrosine kinase.	Epidermal growth factor receptor precursor.	0.938
erbb2	hrasa	ENSDARP00000010252	ENSDARP00000142010	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase a.	0.578
erbb2	igf1	ENSDARP00000010252	ENSDARP00000017449	Receptor protein-tyrosine kinase.	Insulin-like growth factor 1b.	0.690
erbb2	ins	ENSDARP00000010252	ENSDARP00000051221	Receptor protein-tyrosine kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.797
erbb2	insb	ENSDARP00000010252	ENSDARP00000115146	Receptor protein-tyrosine kinase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.805
hrasa	egfra	ENSDARP00000142010	ENSDARP00000125265	HRas proto-oncogene, GTPase a.	Epidermal growth factor receptor precursor.	0.664

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