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gpc3 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By sim [...] (590 aa) | ||||
hspg2 | Heparan sulfate proteoglycan 2. (3462 aa) | ||||
fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) | ||||
gli1 | GLI family zinc finger 1. (1404 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
col2a1a | Collagen, type II, alpha 1a. (1491 aa) | ||||
tnfsf11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa) | ||||
col10a1a | Collagen, type X, alpha 1a. (655 aa) | ||||
tnfaip6 | Tumor necrosis factor, alpha-induced protein 6. (271 aa) | ||||
timp2a | Tissue inhibitor of metalloproteinase 2. (220 aa) | ||||
hhip | Hedgehog-interacting protein. (693 aa) | ||||
ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) | ||||
ptpn11a | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
mmp9 | Matrix metallopeptidase 9. (680 aa) | ||||
acta1b | Actin alpha 1, skeletal muscle b. (377 aa) | ||||
sfrp5 | Secreted frizzled-related protein 5. (310 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
fgfr3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
inhbaa | Inhibin subunit beta Aa. (395 aa) | ||||
timp4.3 | TIMP metallopeptidase inhibitor 4, tandem duplicate 3. (198 aa) | ||||
timp4.1 | TIMP metallopeptidase inhibitor 4, tandem duplicate 1. (229 aa) |