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gpc3 gpc3 hspg2 hspg2 fgf2 fgf2 gli1 gli1 ENSDARP00000125042 ENSDARP00000125042 col2a1a col2a1a tnfsf11 tnfsf11 col10a1a col10a1a tnfaip6 tnfaip6 timp2a timp2a hhip hhip ihhb ihhb ptpn11a ptpn11a ptch2 ptch2 mmp9 mmp9 acta1b acta1b sfrp5 sfrp5 ptch1 ptch1 fgfr3 fgfr3 gli2a gli2a inhbaa inhbaa timp4.3 timp4.3 timp4.1 timp4.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpc3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By sim [...] (590 aa)
hspg2Heparan sulfate proteoglycan 2. (3462 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
gli1GLI family zinc finger 1. (1404 aa)
ENSDARP00000125042Patched 1. (120 aa)
col2a1aCollagen, type II, alpha 1a. (1491 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
col10a1aCollagen, type X, alpha 1a. (655 aa)
tnfaip6Tumor necrosis factor, alpha-induced protein 6. (271 aa)
timp2aTissue inhibitor of metalloproteinase 2. (220 aa)
hhipHedgehog-interacting protein. (693 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
sfrp5Secreted frizzled-related protein 5. (310 aa)
ptch1Protein patched homolog 1. (1475 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
inhbaaInhibin subunit beta Aa. (395 aa)
timp4.3TIMP metallopeptidase inhibitor 4, tandem duplicate 3. (198 aa)
timp4.1TIMP metallopeptidase inhibitor 4, tandem duplicate 1. (229 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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