STRINGSTRING
ifnphi3 ifnphi3 socs5a socs5a sox5 sox5 ifnphi4 ifnphi4 il1b il1b irf1b irf1b tnfsf13b tnfsf13b psmb9a psmb9a casp3a casp3a hsp70.3 hsp70.3 tnfb tnfb rsad2 rsad2 stat1a stat1a hsp90aa1.1 hsp90aa1.1 ifnphi1 ifnphi1 traf3 traf3 socs3a socs3a casp9 casp9 nos2b nos2b sox21a sox21a cd36 cd36 casp6a casp6a socs1a socs1a ifnphi2 ifnphi2 acta1b acta1b irf2 irf2 b2m b2m irf1a irf1a il11b il11b mavs mavs tnfsf11 tnfsf11 irf7 irf7 casp8 casp8 il10 il10 nos2a nos2a tnfsf13 tnfsf13 hsp70.1 hsp70.1 dhx58 dhx58 socs2 socs2 cd28 cd28 ifng1 ifng1 cd83 cd83 tnfaip3 tnfaip3 cd276 cd276 cd79a cd79a ighv1-1 ighv1-1 irf3 irf3 il21r.1 il21r.1 hamp hamp socs7 socs7 cxcl11.1 cxcl11.1 nos1 nos1 irf5 irf5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ifnphi3Interferon phi 3. (182 aa)
socs5aSuppressor of cytokine-signaling 5a. (528 aa)
sox5SRY-box transcription factor 5. (759 aa)
ifnphi4Interferon phi 4. (173 aa)
il1bInterleukin-1. (284 aa)
irf1bInterferon regulatory factor. (287 aa)
tnfsf13bTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (268 aa)
psmb9aProteasome subunit beta. (218 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
rsad2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon; Belongs to the radical SAM superfamily. RSAD2 family. (359 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
ifnphi1Interferon phi 1. (185 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
sox21aTranscription factor Sox-21-A; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo. (239 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
casp6aCaspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (298 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
ifnphi2Type I interferon 2. (181 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
irf2Interferon regulatory factor 2. (256 aa)
b2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (116 aa)
irf1aInterferon regulatory factor. (251 aa)
il11bInterleukin 11b. (192 aa)
mavsMitochondrial antiviral-signaling protein. (364 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
irf7Interferon regulatory factor 7. (422 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
il10Interleukin-10. (180 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
tnfsf13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (199 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
dhx58DEXH (Asp-Glu-X-His) box polypeptide 58. (679 aa)
socs2Suppressor of cytokine signaling 2. (197 aa)
cd28CD28 molecule. (176 aa)
ifng1Interferon gamma 1. (179 aa)
cd83CD83 molecule. (221 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (756 aa)
cd276CD276 molecule. (300 aa)
cd79aCD79a molecule, immunoglobulin-associated alpha. (210 aa)
ighv1-1Immunoglobulin heavy variable 1-1. (116 aa)
irf3Interferon regulatory factor 3. (426 aa)
il21r.1Interleukin 21 receptor, tandem duplicate 1. (523 aa)
hampHepcidin-2; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (91 aa)
socs7Suppressor of cytokine-signaling 7. (777 aa)
cxcl11.1C-X-C motif chemokine 11-1; Ligand for cxcr3.2. Chemotactic for macrophages. (94 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
irf5Interferon regulatory factor 5. (516 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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