node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
X1WHF1_DANRE | hist2h2l | ENSDARP00000129663 | ENSDARP00000055912 | Histone H2B; Belongs to the histone H2B family. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.405 |
hist2h2l | X1WHF1_DANRE | ENSDARP00000055912 | ENSDARP00000129663 | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H2B; Belongs to the histone H2B family. | 0.405 |
jam2a | jam3b | ENSDARP00000132646 | ENSDARP00000082979 | Junctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. | 0.984 |
jam2a | mymk | ENSDARP00000132646 | ENSDARP00000132422 | Junctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | 0.744 |
jam2a | smyhc1 | ENSDARP00000132646 | ENSDARP00000139007 | Junctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. | Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.454 |
jam3b | jam2a | ENSDARP00000082979 | ENSDARP00000132646 | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. | Junctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. | 0.984 |
jam3b | mymk | ENSDARP00000082979 | ENSDARP00000132422 | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | 0.669 |
mylpfa | myog | ENSDARP00000069948 | ENSDARP00000010347 | Myosin light chain, phosphorylatable, fast skeletal muscle a. | Myogenin. | 0.784 |
mylpfa | pax7a | ENSDARP00000069948 | ENSDARP00000138120 | Myosin light chain, phosphorylatable, fast skeletal muscle a. | Transcription factor PAX7C. | 0.546 |
mylpfa | smyhc1 | ENSDARP00000069948 | ENSDARP00000139007 | Myosin light chain, phosphorylatable, fast skeletal muscle a. | Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.923 |
mymk | jam2a | ENSDARP00000132422 | ENSDARP00000132646 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | Junctional adhesion molecule 2A; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes. Belongs to the immunoglobulin superfamily. | 0.744 |
mymk | jam3b | ENSDARP00000132422 | ENSDARP00000082979 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. | 0.669 |
mymk | myog | ENSDARP00000132422 | ENSDARP00000010347 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | Myogenin. | 0.903 |
mymk | pax7a | ENSDARP00000132422 | ENSDARP00000138120 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | Transcription factor PAX7C. | 0.565 |
mymk | six4b | ENSDARP00000132422 | ENSDARP00000048109 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | SIX homeobox 4b. | 0.480 |
myog | mylpfa | ENSDARP00000010347 | ENSDARP00000069948 | Myogenin. | Myosin light chain, phosphorylatable, fast skeletal muscle a. | 0.784 |
myog | mymk | ENSDARP00000010347 | ENSDARP00000132422 | Myogenin. | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. | 0.903 |
myog | pax7a | ENSDARP00000010347 | ENSDARP00000138120 | Myogenin. | Transcription factor PAX7C. | 0.966 |
myog | prdm1a | ENSDARP00000010347 | ENSDARP00000004889 | Myogenin. | PR domain-containing 1a, with ZNF domain. | 0.434 |
myog | six1a | ENSDARP00000010347 | ENSDARP00000057431 | Myogenin. | Homeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. | 0.536 |