STRINGSTRING
mc1r mc1r mknk2b mknk2b mitfb mitfb pnp4a pnp4a paics paics tyrp1a tyrp1a tbpl1 tbpl1 mitfa mitfa tyrp1b tyrp1b gmps gmps pmela pmela ednrba ednrba tyr tyr gart gart
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mc1rMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (323 aa)
mknk2bMAPK-interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
mitfbMicrophthalmia-associated transcription factor b. (500 aa)
pnp4aPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (291 aa)
paicsPhosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase. (1042 aa)
tyrp1aTyrosinase-related protein 1a. (524 aa)
tbpl1TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. (186 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
tyrp1bTyrosinase-related protein 1b. (526 aa)
gmpsGuanine monophosphate synthase. (692 aa)
pmelaPremelanosome protein a. (825 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
tyrTyrosinase. (535 aa)
gartPhosphoribosylglycinamide formyltransferase. (1015 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.