STRINGSTRING
caspbl caspbl tnfrsf1a tnfrsf1a gcgrb gcgrb casr casr myd88 myd88 akt2 akt2 mttp mttp apoa1a apoa1a tlr4bb tlr4bb caspa caspa brd2a brd2a TXN TXN ins ins txnipa txnipa tlr2 tlr2 crp2 crp2 apoeb apoeb selp selp apoba apoba mmp9 mmp9 txn txn irs1 irs1 spire1a spire1a serpine1 serpine1 srebf2 srebf2 hmgcra hmgcra pla2g4aa pla2g4aa gucy1a1 gucy1a1 crp1 crp1 crp6 crp6 il10 il10 tlr4al tlr4al dpp4 dpp4 ace ace crp7 crp7 tet2 tet2 brd4 brd4 pcsk9 pcsk9 tlr4ba tlr4ba crp3 crp3 ace2 ace2 lpl lpl loxa loxa insb insb brd3a brd3a angptl3 angptl3 fap fap ifng1 ifng1 defbl2 defbl2 nlrc5 nlrc5 pla2g4f.1 pla2g4f.1 cdc42 cdc42 pla2g4f.2 pla2g4f.2 pla2g4ab pla2g4ab il6 il6 rela rela hmgcrb hmgcrb NPC1L1 NPC1L1 sirt6 sirt6 LOC101884800 LOC101884800 notch1a notch1a akt3a akt3a il1b il1b ccr2-2 ccr2-2 ccr2 ccr2 pparg pparg vcam1b vcam1b LOC100331214 LOC100331214
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
gcgrbGlucagon receptor b; Belongs to the G-protein coupled receptor 2 family. (509 aa)
casrCalcium-sensing receptor. (946 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
mttpMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (884 aa)
apoa1aProapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
brd2aBromodomain-containing protein 2a. (836 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (108 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
tlr2Toll-like receptor 2. (788 aa)
crp2Pentaxin. (222 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
selpSelectin P. (868 aa)
apobaApolipoprotein Ba. (4418 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
txnThioredoxin; Belongs to the thioredoxin family. (107 aa)
irs1Insulin receptor substrate 1. (1099 aa)
spire1aProtein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with fmn2, promotes assembly of nuclear actin filaments in [...] (761 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
srebf2Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa)
hmgcra3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
pla2g4aaCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa)
gucy1a1Soluble guanylate cyclase large subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (679 aa)
crp1Pentaxin. (225 aa)
crp6Pentaxin. (225 aa)
il10Interleukin-10. (180 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
dpp4Dipeptidyl-peptidase 4; Belongs to the peptidase S9B family. (742 aa)
aceAngiotensin-converting enzyme. (1324 aa)
crp7Pentaxin. (225 aa)
tet2Tet methylcytosine dioxygenase 2. (1715 aa)
brd4Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] (1444 aa)
pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (667 aa)
tlr4baToll-like receptor 4b, duplicate a. (787 aa)
crp3Pentaxin. (223 aa)
ace2Angiotensin-converting enzyme. (818 aa)
lplLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (511 aa)
loxaLysyl oxidase a. (408 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
brd3aBromodomain-containing 3a. (683 aa)
angptl3Angiopoietin-like 3. (466 aa)
fapFibroblast activation protein, alpha; Belongs to the peptidase S9B family. (750 aa)
ifng1Interferon gamma 1. (179 aa)
defbl2Defensin, beta-like 2. (65 aa)
nlrc5NLR family, CARD domain-containing 5. (1746 aa)
pla2g4f.1Phospholipase A2. (837 aa)
cdc42Cell division cycle 42. (191 aa)
pla2g4f.2Phospholipase A2. (809 aa)
pla2g4abPhospholipase A2. (720 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1085 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
LOC101884800PLAT domain-containing protein. (530 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
il1bInterleukin-1. (284 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
LOC100331214PLAT domain-containing protein. (502 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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