STRINGSTRING
sufu sufu prkacab prkacab map2k1 map2k1 gli2a gli2a smo smo xiap xiap rhoab rhoab akt2 akt2 prkacba prkacba ptch1 ptch1 tgfb3 tgfb3 dyrk1b dyrk1b gnai3 gnai3 shhb shhb rhebl1 rhebl1 gli3 gli3 tgfb1a tgfb1a stk11 stk11 ptch2 ptch2 gpr161 gpr161 ptenb ptenb prkacbb prkacbb dyrk1aa dyrk1aa wdr35 wdr35 pdgfra pdgfra mapk3 mapk3 dyrk4 dyrk4 tgfb5 tgfb5 myca myca dyrk3 dyrk3 smad2 smad2 rheb rheb gnas gnas ulk1b ulk1b mlst8 mlst8 rictorb rictorb tgfb1b tgfb1b prkag2b prkag2b dyrk2 dyrk2 deptor deptor ENSDARP00000125042 ENSDARP00000125042 shha shha nf1a nf1a gli1 gli1 tsc2 tsc2 prkacaa prkacaa ccnd1 ccnd1 ift20 ift20 DYNC2H1 DYNC2H1 nkx2.2a nkx2.2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sufuSuppressor of fused homolog. (485 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
xiapX-linked inhibitor of apoptosis. (405 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
dyrk1bDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1B. (751 aa)
gnai3Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3. (354 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
gli3GLI family zinc finger 3. (1553 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
dyrk1aaDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, a. (737 aa)
wdr35WD repeat-containing protein 35. (1203 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
dyrk4Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 4. (634 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
dyrk3Dual-specificity tyrosine phosphorylation-regulated kinase 3. (582 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
gnasGNAS complex locus. (379 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
mlst8Target of rapamycin complex subunit lst8. (326 aa)
rictorbRPTOR-independent companion of MTOR, complex 2b. (1698 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
prkag2bProtein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (533 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2. (587 aa)
deptorDEP domain-containing MTOR-interacting protein. (407 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
nf1aNeurofibromin 1a. (2759 aa)
gli1GLI family zinc finger 1. (1404 aa)
tsc2TSC complex subunit 2. (1674 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
ift20Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. (132 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4208 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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