STRINGSTRING
atoh1a atoh1a asns asns whrnb whrnb thbs1b thbs1b gpt2l gpt2l tgfb1b tgfb1b hars hars pou4f3 pou4f3 cep290 cep290 shha shha ush1gb ush1gb thbs1a thbs1a myo7aa myo7aa pcdh15b pcdh15b clrn1 clrn1 pdzd7a pdzd7a pcdh15a pcdh15a cib2 cib2 mmp2 mmp2 msna msna tgfb3 tgfb3 cdh23 cdh23 shhb shhb acta1b acta1b ENSDARP00000060652 ENSDARP00000060652 tgfb1a tgfb1a mmp9 mmp9 egf egf ush2a ush2a TMC1 TMC1 src src fn1b fn1b tgfb5 tgfb5 whrna whrna ank1a ank1a gpt2 gpt2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atoh1aAtonal bHLH transcription factor 1a. (292 aa)
asnsAsparagine synthetase [glutamine-hydrolyzing]. (560 aa)
whrnbWhirlin b. (946 aa)
thbs1bThrombospondin 1b. (1171 aa)
gpt2lAlanine aminotransferase 2-like; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. (562 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
harsHistidine--tRNA ligase; Catalyzes the aminoacylation of histidyl-tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family. (520 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
thbs1aThrombospondin 1a. (795 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
clrn1Clrn1 protein. (232 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
msnaMoesin a. (579 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
cdh23Cadherin-related 23. (2883 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ENSDARP00000060652Si:ch211-57i17.5. (199 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
egfEpidermal growth factor. (1114 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
fn1bFibronectin 1b. (2500 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
whrnaWhirlin a. (939 aa)
ank1aAnkyrin 1, erythrocytic a. (152 aa)
gpt2Glutamic pyruvate transaminase (alanine aminotransferase) 2. (545 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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