STRINGSTRING
bdnf bdnf tnfb tnfb gpx4b gpx4b pdgfba pdgfba atf2 atf2 vcam1b vcam1b iapp iapp pparg pparg il1b il1b nr1h3 nr1h3 gcgra gcgra hhex hhex gphna gphna igfbp1a igfbp1a nos1 nos1 gphnb gphnb cnn1b cnn1b bace1 bace1 X1WHF1_DANRE X1WHF1_DANRE LOC100330746 LOC100330746 gpx9 gpx9 abcc8 abcc8 gpx7 gpx7 bcl2a bcl2a vamp1 vamp1 mpc1 mpc1 mlxip mlxip insb insb cdkn1a cdkn1a ulk1b ulk1b gcgb gcgb prdm16 prdm16 nos2a nos2a neurog3 neurog3 mafb mafb scg5 scg5 myca myca tgfbi tgfbi stat3 stat3 pik3c3 pik3c3 gpx4a gpx4a sirt1 sirt1 srebf1 srebf1 timp2a timp2a slc2a2 slc2a2 pdk4 pdk4 pcna pcna gapdh gapdh gpx3 gpx3 gcga gcga nfe2l2a nfe2l2a mmp9 mmp9 sod2 sod2 ren ren apoeb apoeb eif4a1a eif4a1a hist2h2l hist2h2l mnx1 mnx1 ins ins nos2b nos2b gsr gsr fosab fosab cryba2a cryba2a myh11a myh11a ucp1 ucp1 cycsb cycsb mpc2 mpc2 neurod1 neurod1 nqo1 nqo1 gpx1a gpx1a mapkapk2a mapkapk2a mafba mafba sst2 sst2 pax4 pax4 gcgrb gcgrb isl1 isl1 gpx8 gpx8 gpx1b gpx1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
atf2Activating transcription factor 2. (515 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
iappCALCITONIN domain-containing protein. (124 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
il1bInterleukin-1. (284 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
gcgraGlucagon receptor a; Belongs to the G-protein coupled receptor 2 family. (520 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
gphnaGephyrin a. (868 aa)
igfbp1aInsulin-like growth factor-binding protein 1a. (262 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
gphnbGephyrin2 isoform. (796 aa)
cnn1bCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (296 aa)
bace1Beta-secretase 1; Belongs to the peptidase A1 family. (221 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
LOC100330746Secretogranin V. (219 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 8. (1581 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
vamp1Vesicle-associated membrane protein 1. (119 aa)
mpc1Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (109 aa)
mlxipMLX-interacting protein. (851 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
gcgbGlucagon b. (124 aa)
prdm16Si:ch211-263k4.2. (927 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
neurog3Neurog3 protein. (208 aa)
mafbTranscription factor Maf; Acts as a transcriptional activator or repressor. Belongs to the bZIP family. Maf subfamily. (327 aa)
scg5Secretogranin V. (219 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
tgfbiTransforming growth factor, beta-induced. (677 aa)
stat3Signal transducer and activator of transcription. (806 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
sirt1Sirtuin 1. (710 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
timp2aTissue inhibitor of metalloproteinase 2. (220 aa)
slc2a2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (504 aa)
pdk4Protein-serine/threonine kinase. (409 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
gcgaGlucagon a. (121 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
renRenin; Belongs to the peptidase A1 family. (395 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
eif4a1aEukaryotic translation initiation factor 4A, isoform 1A. (406 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
mnx1Motor neuron and pancreas homeobox 1. (311 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
gsrGlutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
cryba2aCrystallin, beta A2a; Belongs to the beta/gamma-crystallin family. (197 aa)
myh11aMyosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
ucp1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
mpc2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
neurod1Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (350 aa)
nqo1NAD(P)H dehydrogenase, quinone 1. (275 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
mapkapk2aMitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily. (382 aa)
mafbaTranscription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa)
sst2Somatostatin 2. (107 aa)
pax4Paired box 4. (344 aa)
gcgrbGlucagon receptor b; Belongs to the G-protein coupled receptor 2 family. (509 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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