(52 nodes) (2021) Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways. network (Danio rerio)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	cyba	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (185 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (408 aa)
	sting1	Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). [...] (398 aa)
	scdb	Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. (316 aa)
	vcam1b	Vascular cell adhesion molecule 1b. (808 aa)
	pparg	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
	ccr2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ccr2-2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	postnb	Periostin, osteoblast-specific factor b. (782 aa)
	sctr	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (445 aa)
	abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3. (1538 aa)
	pnpla3	Patatin-like phospholipase domain-containing 3. (473 aa)
	ccn2b	Connective tissue growth factor-like protein. (351 aa)
	lcat	Lecithin-cholesterol acyltransferase. (425 aa)
	sphk2	Sphingosine kinase 2. (869 aa)
	got1	Aspartate aminotransferase. (410 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (681 aa)
	abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4. (1275 aa)
	nceh1a	Neutral cholesterol ester hydrolase 1a. (408 aa)
	tgfb1b	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	cerk	Ceramide kinase. (649 aa)
	cyp7a1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	caspbl	Caspase b,-like; Belongs to the peptidase C14A family. (409 aa)
	fasn	Coiled-coil domain containing 57. (2511 aa)
	loxl1	Lysyl oxidase-like 1. (526 aa)
	cyp8b1	Cytochrome P450, family 8, subfamily B, polypeptide 1. (521 aa)
	ces2a	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (555 aa)
	ncf2	Neutrophil cytosolic factor 2. (500 aa)
	sirt1	Sirtuin 1. (710 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
	srebf1	Sterol regulatory element-binding transcription factor 1. (879 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	nceh1b.1	Neutral cholesterol ester hydrolase 1b, tandem duplicate 1. (408 aa)
	ccn2a	Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (483 aa)
	tgfb1a	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	got2a	Aspartate aminotransferase. (428 aa)
	ncf4	Neutrophil cytosolic factor 4. (355 aa)
	acta1b	Actin alpha 1, skeletal muscle b. (377 aa)
	s1pr2	Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)
	ncf1	Neutrophil cytosolic factor 1. (410 aa)
	mpx	Myeloid-specific peroxidase. (893 aa)
	zgc:158263	Zgc:158263. (574 aa)
	caspa	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
	ifnphi1	Interferon phi 1. (185 aa)
	cd63	Tetraspanin. (237 aa)
	elovl5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (291 aa)
	got2b	Aspartate aminotransferase. (428 aa)
	cyp7b1	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (504 aa)
	postna	Periostin, osteoblast-specific factor a. (882 aa)
	si:dkey-32n7.4	Si:dkey-32n7.4; Belongs to the integrin alpha chain family. (1136 aa)
	tnfb	Tumor necrosis factor b (TNF superfamily, member 2). (242 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYTB	acta1b	ENSDARP00000087881	ENSDARP00000058628	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Actin alpha 1, skeletal muscle b.	0.407
CYTB	cyba	ENSDARP00000087881	ENSDARP00000014491	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.	0.446
CYTB	ncf1	ENSDARP00000087881	ENSDARP00000050897	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Neutrophil cytosolic factor 1.	0.529
CYTB	ncf4	ENSDARP00000087881	ENSDARP00000059819	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Neutrophil cytosolic factor 4.	0.417
NCEH1	acsl5	ENSDARP00000154307	ENSDARP00000123999	Neutral cholesterol ester hydrolase 1.	Acyl-CoA synthetase long chain family member 5.	0.446
NCEH1	ces2a	ENSDARP00000154307	ENSDARP00000090963	Neutral cholesterol ester hydrolase 1.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.525
NCEH1	elovl5	ENSDARP00000154307	ENSDARP00000027516	Neutral cholesterol ester hydrolase 1.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.420
NCEH1	fasn	ENSDARP00000154307	ENSDARP00000112100	Neutral cholesterol ester hydrolase 1.	Coiled-coil domain containing 57.	0.489
NCEH1	lcat	ENSDARP00000154307	ENSDARP00000132129	Neutral cholesterol ester hydrolase 1.	Lecithin-cholesterol acyltransferase.	0.553
NCEH1	pnpla3	ENSDARP00000154307	ENSDARP00000139211	Neutral cholesterol ester hydrolase 1.	Patatin-like phospholipase domain-containing 3.	0.498
NCEH1	scdb	ENSDARP00000154307	ENSDARP00000147880	Neutral cholesterol ester hydrolase 1.	Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family.	0.490
NCEH1	srebf1	ENSDARP00000154307	ENSDARP00000087097	Neutral cholesterol ester hydrolase 1.	Sterol regulatory element-binding transcription factor 1.	0.407
abcb4	abcc3	ENSDARP00000123836	ENSDARP00000139878	ATP-binding cassette, sub-family B (MDR/TAP), member 4.	ATP-binding cassette, sub-family C (CFTR/MRP), member 3.	0.503
abcb4	abcg5	ENSDARP00000123836	ENSDARP00000086278	ATP-binding cassette, sub-family B (MDR/TAP), member 4.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.430
abcb4	nr1h4	ENSDARP00000123836	ENSDARP00000061793	ATP-binding cassette, sub-family B (MDR/TAP), member 4.	Nuclear receptor subfamily 1, group H, member 4.	0.403
abcc3	abcb4	ENSDARP00000139878	ENSDARP00000123836	ATP-binding cassette, sub-family C (CFTR/MRP), member 3.	ATP-binding cassette, sub-family B (MDR/TAP), member 4.	0.503
abcc3	abcg5	ENSDARP00000139878	ENSDARP00000086278	ATP-binding cassette, sub-family C (CFTR/MRP), member 3.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.460
abcg5	abcb4	ENSDARP00000086278	ENSDARP00000123836	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family B (MDR/TAP), member 4.	0.430
abcg5	abcc3	ENSDARP00000086278	ENSDARP00000139878	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family C (CFTR/MRP), member 3.	0.460
abcg5	cyp7a1	ENSDARP00000086278	ENSDARP00000113850	ATP-binding cassette, sub-family G (WHITE), member 5.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.777

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