STRINGSTRING
ect2 ect2 hcls1 hcls1 itga2.1 itga2.1 rock2a rock2a actn1 actn1 pacsin2 pacsin2 hdac6 hdac6 wipf1b wipf1b X1WCU6_DANRE X1WCU6_DANRE cdc42 cdc42 gpib gpib epob epob rock1 rock1 Flnb Flnb arpc2 arpc2 actr2b actr2b src src pfn2 pfn2 iqgap1 iqgap1 epoa epoa thpo thpo vwf vwf rac2 rac2 rabif rabif pfn1 pfn1 actn3b actn3b mpl mpl runx1 runx1 flna flna cttn cttn rhoab rhoab zgc:101810 zgc:101810 flncb flncb rhogb rhogb ifnphi1 ifnphi1 tpm4a tpm4a arpc1b arpc1b flnca flnca flnb flnb pfn2l pfn2l cxcl12a cxcl12a acta1b acta1b cxcr4b cxcr4b actr2a actr2a tubb1 tubb1 srfa srfa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ect2Epithelial cell-transforming 2. (976 aa)
hcls1Hematopoietic cell-specific Lyn substrate 1. (548 aa)
itga2.1Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 1. (254 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
actn1Actinin, alpha 1. (902 aa)
pacsin2Protein kinase C and casein kinase substrate in neurons 2. (490 aa)
hdac6Histone deacetylase 6. (1081 aa)
wipf1bWAS/WASL-interacting protein family, member 1b. (485 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
cdc42Cell division cycle 42. (191 aa)
gpibGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
epobErythropoietin b. (217 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
FlnbUncharacterized protein. (157 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
epoaErythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (183 aa)
thpoThrombopoietin. (191 aa)
vwfVon Willebrand factor. (2812 aa)
rac2Rac family small GTPase 2. (219 aa)
rabifRAB-interacting factor. (132 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
actn3bActinin alpha 3b. (898 aa)
mplMPL proto-oncogene, thrombopoietin receptor. (614 aa)
runx1Runt-related transcription factor. (451 aa)
flnaFilamin A, alpha (actin-binding protein 280). (2553 aa)
cttnCortactin. (536 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
flncbFilamin C, gamma b (actin-binding protein 280). (2773 aa)
rhogbRas homolog gene family, member Gb. (191 aa)
ifnphi1Interferon phi 1. (185 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
arpc1bActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
flncaFilamin C, gamma a (actin-binding protein 280). (2719 aa)
flnbFilamin B, beta (actin-binding protein 278). (2233 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
tubb1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
srfaSerum response factor a. (539 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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