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fgf13b fgf13b hoxb6a hoxb6a nradd nradd mcm3 mcm3 hoxb5a hoxb5a cldn7b cldn7b hoxa11b hoxa11b mmp2 mmp2 cdh11 cdh11 hoxb6b hoxb6b slc18a3a slc18a3a dla dla barx1 barx1 vim vim hand2 hand2 hoxa2b hoxa2b slc18a2 slc18a2 neurod1 neurod1 pou3f1 pou3f1 six1b six1b elavl3 elavl3 pnp4a pnp4a tbx5a tbx5a sparc sparc prrx1a prrx1a twist1a twist1a hoxb8a hoxb8a hoxa10b hoxa10b trpm1a trpm1a hoxa13b hoxa13b calb2b calb2b oprd1b oprd1b mcm3l mcm3l aurkb aurkb ascl1a ascl1a mitfa mitfa six1a six1a rgs16 rgs16 epcam epcam ckmb ckmb olig2 olig2 calb2a calb2a prrx1b prrx1b tuba8l tuba8l abracl abracl gpx3 gpx3 sox9b sox9b tuba2 tuba2 snai1b snai1b hoxb5b hoxb5b pcna pcna hoxb7a hoxb7a hoxb3a hoxb3a neurog1 neurog1 tyrp1b tyrp1b hoxa9b hoxa9b gng2 gng2 stx1b stx1b hoxd13a hoxd13a hoxd12a hoxd12a hoxd9a hoxd9a hoxd4a hoxd4a gata2a gata2a slc32a1 slc32a1 colec12 colec12 gpnmb gpnmb slc6a5 slc6a5 cldna cldna hoxc1a hoxc1a tnnt3a tnnt3a pdgfra pdgfra tnnc2 tnnc2 oprl1 oprl1 meox1 meox1 vipb vipb sox10 sox10 vip vip dlx2a dlx2a foxc1a foxc1a otomp otomp foxd3 foxd3 insm1a insm1a pmela pmela pax7b pax7b gad1b gad1b dct dct snai1a snai1a elavl4 elavl4 hoxb2a hoxb2a hoxd3a hoxd3a tnnt3b tnnt3b hoxc5a hoxc5a hoxb1b hoxb1b neurod4 neurod4 ngfrb ngfrb nova2 nova2 galn galn mych mych meis3 meis3 hoxc3a hoxc3a gfra1a gfra1a etv1 etv1 actc1b actc1b phox2bb phox2bb gch2 gch2 ncam1a ncam1a mmp17b mmp17b hoxa11a hoxa11a hoxc12b hoxc12b hoxa5a hoxa5a trpm1b trpm1b aox5 aox5 lmo1 lmo1 SMIM18 SMIM18 pbx3b pbx3b notch1a notch1a hoxa3a hoxa3a tfec tfec tfap2e tfap2e hoxa9a hoxa9a crestin crestin tpma tpma zeb2a zeb2a ntng1a ntng1a tfap2a tfap2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf13bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (257 aa)
hoxb6aHomeobox protein Hox-B6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (228 aa)
nraddNeurotrophin receptor-associated death domain. (413 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
hoxb5aHomeobox protein Hox-B5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (275 aa)
cldn7bClaudin-7-B; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. (215 aa)
hoxa11bHomeobox protein Hox-A11b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (283 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
cdh11Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
hoxb6bHomeobox protein Hox-B6b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (224 aa)
slc18a3aProbable vesicular acetylcholine transporter-A; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (513 aa)
dlaDelta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa)
barx1Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
hoxa2bHomeobox protein Hox-A2b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (363 aa)
slc18a2Solute carrier family 18 member 2. (562 aa)
neurod1Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (350 aa)
pou3f1POU domain, class 3, transcription factor 1; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal; Belongs to the POU transcription factor family. Class-3 subfamily. (368 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
elavl3ELAV-like protein; Belongs to the RRM elav family. (359 aa)
pnp4aPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (291 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
sparcSecreted protein, acidic, cysteine-rich (osteonectin). (291 aa)
prrx1aPaired-related homeobox 1a. (245 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
hoxb8aHomeobox protein Hox-B8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (245 aa)
hoxa10bHomeobox protein Hox-A10b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (330 aa)
trpm1aTransient receptor potential cation channel, subfamily M, member 1a. (1546 aa)
hoxa13bHomeobox protein Hox-A13b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (289 aa)
calb2bCalbindin 2b. (269 aa)
oprd1bOpioid receptor, delta 1b; Belongs to the G-protein coupled receptor 1 family. (375 aa)
mcm3lDNA helicase; Belongs to the MCM family. (807 aa)
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (320 aa)
ascl1aAchaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. (196 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
six1aHomeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. (283 aa)
rgs16Regulator of G protein-signaling 16. (209 aa)
epcamEpithelial cell adhesion molecule. (303 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
calb2aCalbindin 2, like. (271 aa)
prrx1bPaired-related homeobox 1b. (245 aa)
tuba8lTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
abraclCostars family protein ABRACL; Belongs to the costars family. (81 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
tuba2Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
snai1bSnail family zinc finger 1b. (256 aa)
hoxb5bHomeobox protein Hox-B5b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (276 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
hoxb7aHomeobox protein Hox-B7a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (227 aa)
hoxb3aHomeobox protein Hox-B3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (417 aa)
neurog1Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa)
tyrp1bTyrosinase-related protein 1b. (526 aa)
hoxa9bHomeobox protein Hox-A9b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (253 aa)
gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
stx1bSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
hoxd13aHomeobox protein Hox-D13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (256 aa)
hoxd12aHomeobox protein Hox-D12a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (277 aa)
hoxd9aHomeobox protein Hox-D9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (262 aa)
hoxd4aHomeobox protein Hox-D4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (256 aa)
gata2aGATA-binding protein 2a. (456 aa)
slc32a1Solute carrier family 32 (GABA vesicular transporter), member 1. (530 aa)
colec12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity). (720 aa)
gpnmbGlycoprotein (transmembrane) nmb. (627 aa)
slc6a5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (786 aa)
cldnaClaudin a. (206 aa)
hoxc1aHomeobox protein Hox-C1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (302 aa)
tnnt3aTroponin T type 3a (skeletal, fast). (230 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
oprl1Opioid receptor-like protein Zf-orl; Belongs to the G-protein coupled receptor 1 family. (363 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
vipbVasoactive intestinal peptide b. (151 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
vipVasoactive intestinal peptide. (153 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
foxc1aForkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa)
otompOtolith matrix protein 1; Required for normal otolith growth and deposition of otolin-1 in the otolith. (371 aa)
foxd3Forkhead box D3. (371 aa)
insm1aInsulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa)
pmelaPremelanosome protein a. (825 aa)
pax7bPaired box protein 7b. (510 aa)
gad1bGlutamate decarboxylase 1b. (613 aa)
dctDopachrome tautomerase. (513 aa)
snai1aSnail family zinc finger 1a. (260 aa)
elavl4ELAV-like protein 4; RNA-binding protein that is involved in the post- transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Required for the maturation of motor neuron axonal branches and dendrites. (408 aa)
hoxb2aHomeobox protein Hox-B2a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Plays an important role in the patterning of hindbrain and pharyngeal arches. (409 aa)
hoxd3aHomeobox protein Hox-D3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (396 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
hoxc5aHomeobox protein Hox-C5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (213 aa)
hoxb1bHomeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa)
neurod4Neurogenic differentiation factor. (348 aa)
ngfrbNerve growth factor receptor b. (431 aa)
nova2NOVA alternative-splicing regulator 2. (517 aa)
galnGalanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1 (galr1a and galr1b) and GALR2 (galr2a and galr2b). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. (142 aa)
mychTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (360 aa)
meis3Myeloid ecotropic viral integration site 3. (415 aa)
hoxc3aHomeobox protein Hox-C3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (257 aa)
gfra1aGdnf family receptor alpha 1a. (97 aa)
etv1ETS variant transcription factor 1. (476 aa)
actc1bActin, alpha 1, skeletal muscle. (377 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
gch2GTP cyclohydrolase 2. (240 aa)
ncam1aNeural cell adhesion molecule 1a. (898 aa)
mmp17bMatrix metallopeptidase 17b. (613 aa)
hoxa11aHomeobox protein Hox-A11a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (284 aa)
hoxc12bHomeobox protein Hox-C12b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (283 aa)
hoxa5aHomeobox protein Hox-A5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (265 aa)
trpm1bTransient receptor potential cation channel, subfamily M, member 1b. (1594 aa)
aox5Aldehyde oxidase alpha. (1336 aa)
lmo1Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. (175 aa)
SMIM18Si:dkey-92j12.6. (70 aa)
pbx3bPre-B-cell leukemia transcription factor 3b. (386 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
hoxa3aHomeobox protein Hox-A3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (410 aa)
tfecTranscription factor EC. (396 aa)
tfap2eTranscription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions. (432 aa)
hoxa9aHomeobox protein Hox-A9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (250 aa)
crestinCrestin. (593 aa)
tpmaTropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (284 aa)
zeb2aZinc finger E-box-binding homeobox 2a. (1242 aa)
ntng1aNetrin g1a. (546 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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